Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients
Background The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post-transplantation period (PTP).Methods A prospective study incl...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313863 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591075347267584 |
|---|---|
| author | Mariam Ammar Soumaya Yaich Ahmed Hakim Hanen Ghozzi Zouheir Sahnoun Mohamed Ben Hmida Khaled Zghal Lobna Ben Mahmoud |
| author_facet | Mariam Ammar Soumaya Yaich Ahmed Hakim Hanen Ghozzi Zouheir Sahnoun Mohamed Ben Hmida Khaled Zghal Lobna Ben Mahmoud |
| author_sort | Mariam Ammar |
| collection | DOAJ |
| description | Background The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post-transplantation period (PTP).Methods A prospective study including 90 KT patients was performed. TAC whole-blood concentrations were measured by the microparticle enzyme immunoassay method and adjusted according to the target range. Plasma levels of oxidants (malondialdehyde (MDA) and advanced oxidation protein products (AOPP)) and antioxidants (ascorbic acid, glutathione (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) were measured using spectrophotometry. The subjects were subdivided according to PTP into three groups: patients with early, intermediate, and late PT. According to the TAC level, they were subdivided into LL-TAC, NL-TAC, and HL-TAC groups.Results A decrease in MDA levels, SOD activity, and an increase in GSH levels and GPx activity were observed in patients with late PT compared to those with early and intermediate PT (p < 0.05). Patients with LL-TAC had lower MDA levels and higher GSH levels and GPx activity compared with the NL-TAC and HL-TAC groups (p < 0.05).Conclusion Our results have shown that in KT patients, despite the recovery of kidney function, the TAC reduced but did not normalize oxidative stress levels in long-term therapy, and the TAC effect significantly depends on the concentration used. |
| format | Article |
| id | doaj-art-04a4eed0419f42fe809631e2f5844d6c |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-04a4eed0419f42fe809631e2f5844d6c2025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2313863Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patientsMariam Ammar0Soumaya Yaich1Ahmed Hakim2Hanen Ghozzi3Zouheir Sahnoun4Mohamed Ben Hmida5Khaled Zghal6Lobna Ben Mahmoud7Department of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, TunisiaDepartment of Nephrology, Hedi Chaker University Hospital, University of Sfax, Sfax, TunisiaDepartment of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, TunisiaDepartment of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, TunisiaDepartment of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, TunisiaDepartment of Nephrology, Hedi Chaker University Hospital, University of Sfax, Sfax, TunisiaDepartment of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, TunisiaDepartment of Pharmacology, Faculty of Medicine, University of Sfax, Sfax, TunisiaBackground The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post-transplantation period (PTP).Methods A prospective study including 90 KT patients was performed. TAC whole-blood concentrations were measured by the microparticle enzyme immunoassay method and adjusted according to the target range. Plasma levels of oxidants (malondialdehyde (MDA) and advanced oxidation protein products (AOPP)) and antioxidants (ascorbic acid, glutathione (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) were measured using spectrophotometry. The subjects were subdivided according to PTP into three groups: patients with early, intermediate, and late PT. According to the TAC level, they were subdivided into LL-TAC, NL-TAC, and HL-TAC groups.Results A decrease in MDA levels, SOD activity, and an increase in GSH levels and GPx activity were observed in patients with late PT compared to those with early and intermediate PT (p < 0.05). Patients with LL-TAC had lower MDA levels and higher GSH levels and GPx activity compared with the NL-TAC and HL-TAC groups (p < 0.05).Conclusion Our results have shown that in KT patients, despite the recovery of kidney function, the TAC reduced but did not normalize oxidative stress levels in long-term therapy, and the TAC effect significantly depends on the concentration used.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313863Tacrolimuspost-transplantationoxidative stresstrough level |
| spellingShingle | Mariam Ammar Soumaya Yaich Ahmed Hakim Hanen Ghozzi Zouheir Sahnoun Mohamed Ben Hmida Khaled Zghal Lobna Ben Mahmoud Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients Renal Failure Tacrolimus post-transplantation oxidative stress trough level |
| title | Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients |
| title_full | Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients |
| title_fullStr | Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients |
| title_full_unstemmed | Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients |
| title_short | Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients |
| title_sort | tacrolimus trough level and oxidative stress in tunisian kidney transplanted patients |
| topic | Tacrolimus post-transplantation oxidative stress trough level |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313863 |
| work_keys_str_mv | AT mariamammar tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT soumayayaich tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT ahmedhakim tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT hanenghozzi tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT zouheirsahnoun tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT mohamedbenhmida tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT khaledzghal tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients AT lobnabenmahmoud tacrolimustroughlevelandoxidativestressintunisiankidneytransplantedpatients |