Overview of current NGS testing for male factor infertility
Aim — Infertility is a global health problem. The next-generation sequencing and panel testing are offering new opportunities to further diagnose the reason for male infertility. The aim of this paper is to provide a better insight into the currently available panels for male infertility due to impa...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Limited liability company «Science and Innovations» (Saratov)
2022-03-01
|
| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | https://romj.org/node/452 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849697126027624448 |
|---|---|
| author | Mariya Levkova Trifon Chervenkov Mari Hachmeriyan Lyudmila Angelova |
| author_facet | Mariya Levkova Trifon Chervenkov Mari Hachmeriyan Lyudmila Angelova |
| author_sort | Mariya Levkova |
| collection | DOAJ |
| description | Aim — Infertility is a global health problem. The next-generation sequencing and panel testing are offering new opportunities to further diagnose the reason for male infertility. The aim of this paper is to provide a better insight into the currently available panels for male infertility due to impaired spermatogenesis.
Methods — We conducted research in the Genetic testing registry by using the keywords „infertility“, „male infertility“. We also gathered information about the number of tested genes, coverage of the panels, turnaround time, and any additional tests, which could be ordered.
Results — As a result there were eleven laboratories, offering panel testing for male infertility, which tested for 230 different genes, but 65 genes (28.26%) from the different panels had an uncertain role for the tested condition. Cystic fibrosis transmembrane conductance regulator was the only gene, suggested by all laboratories.
Conclusions — Next-generation sequencing could be extremely helpful in the diagnostic process of male infertility. However, clinicians should be aware that some of the included genes have an uncertain role for male infertility. |
| format | Article |
| id | doaj-art-049a609cf9c6411ab4f0b529e497d7d8 |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-049a609cf9c6411ab4f0b529e497d7d82025-08-20T03:19:17ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152022-03-01111e010110.15275/rusomj.2022.0101Overview of current NGS testing for male factor infertilityMariya LevkovaTrifon ChervenkovMari HachmeriyanLyudmila AngelovaAim — Infertility is a global health problem. The next-generation sequencing and panel testing are offering new opportunities to further diagnose the reason for male infertility. The aim of this paper is to provide a better insight into the currently available panels for male infertility due to impaired spermatogenesis. Methods — We conducted research in the Genetic testing registry by using the keywords „infertility“, „male infertility“. We also gathered information about the number of tested genes, coverage of the panels, turnaround time, and any additional tests, which could be ordered. Results — As a result there were eleven laboratories, offering panel testing for male infertility, which tested for 230 different genes, but 65 genes (28.26%) from the different panels had an uncertain role for the tested condition. Cystic fibrosis transmembrane conductance regulator was the only gene, suggested by all laboratories. Conclusions — Next-generation sequencing could be extremely helpful in the diagnostic process of male infertility. However, clinicians should be aware that some of the included genes have an uncertain role for male infertility.https://romj.org/node/452male infertilitynext-generation sequencingpanel testing |
| spellingShingle | Mariya Levkova Trifon Chervenkov Mari Hachmeriyan Lyudmila Angelova Overview of current NGS testing for male factor infertility Russian Open Medical Journal male infertility next-generation sequencing panel testing |
| title | Overview of current NGS testing for male factor infertility |
| title_full | Overview of current NGS testing for male factor infertility |
| title_fullStr | Overview of current NGS testing for male factor infertility |
| title_full_unstemmed | Overview of current NGS testing for male factor infertility |
| title_short | Overview of current NGS testing for male factor infertility |
| title_sort | overview of current ngs testing for male factor infertility |
| topic | male infertility next-generation sequencing panel testing |
| url | https://romj.org/node/452 |
| work_keys_str_mv | AT mariyalevkova overviewofcurrentngstestingformalefactorinfertility AT trifonchervenkov overviewofcurrentngstestingformalefactorinfertility AT marihachmeriyan overviewofcurrentngstestingformalefactorinfertility AT lyudmilaangelova overviewofcurrentngstestingformalefactorinfertility |