The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition

Diet is a complex exposure that affects health across the lifespan. Objective biomarkers that can reliably reflect intake of nutrients, foods, and dietary patterns with sufficient accuracy are an important tool for assessing associations of diet with health outcomes. Advances in metabolomics, couple...

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Main Authors: Hrishikesh Chakraborty, Qi Sun, Shilpa N Bhupathiraju, Jeannette M Schenk, Darya O Mishchuk, James R Bain, Xuan He, Jianghao Sun, James Harnly, William Simmons, Daniel Raftery, Liming Liang, John W Newman, Oliver Fiehn, Clary B Clish, Johanna W Lampe, Brian J Bennett, Sandi L Navarro, Ying Wang, Cheng Zheng, Yasmin Mossavar-Rahmani, Marjorie L McCullough, Ying Huang, Ali Shojaie, Wentao Zhu, Danijel Djukovic, Frank Sacks, Jonathan Williams, Francene M Steinberg, Sean H Adams, Frank B Hu, Marian L Neuhouser, Carolyn M Slupsky, Padma Maruvada
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Current Developments in Nutrition
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Online Access:http://www.sciencedirect.com/science/article/pii/S2475299125028951
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author Hrishikesh Chakraborty
Qi Sun
Shilpa N Bhupathiraju
Jeannette M Schenk
Darya O Mishchuk
James R Bain
Xuan He
Jianghao Sun
James Harnly
William Simmons
Daniel Raftery
Liming Liang
John W Newman
Oliver Fiehn
Clary B Clish
Johanna W Lampe
Brian J Bennett
Sandi L Navarro
Ying Wang
Cheng Zheng
Yasmin Mossavar-Rahmani
Marjorie L McCullough
Ying Huang
Ali Shojaie
Wentao Zhu
Danijel Djukovic
Frank Sacks
Jonathan Williams
Francene M Steinberg
Sean H Adams
Frank B Hu
Marian L Neuhouser
Carolyn M Slupsky
Padma Maruvada
author_facet Hrishikesh Chakraborty
Qi Sun
Shilpa N Bhupathiraju
Jeannette M Schenk
Darya O Mishchuk
James R Bain
Xuan He
Jianghao Sun
James Harnly
William Simmons
Daniel Raftery
Liming Liang
John W Newman
Oliver Fiehn
Clary B Clish
Johanna W Lampe
Brian J Bennett
Sandi L Navarro
Ying Wang
Cheng Zheng
Yasmin Mossavar-Rahmani
Marjorie L McCullough
Ying Huang
Ali Shojaie
Wentao Zhu
Danijel Djukovic
Frank Sacks
Jonathan Williams
Francene M Steinberg
Sean H Adams
Frank B Hu
Marian L Neuhouser
Carolyn M Slupsky
Padma Maruvada
author_sort Hrishikesh Chakraborty
collection DOAJ
description Diet is a complex exposure that affects health across the lifespan. Objective biomarkers that can reliably reflect intake of nutrients, foods, and dietary patterns with sufficient accuracy are an important tool for assessing associations of diet with health outcomes. Advances in metabolomics, coupled with feeding trials and high-dimensional bioinformatics analyses, pave the way for discovering compounds that can serve as sensitive and specific biomarkers of dietary exposures. The Dietary Biomarkers Development Consortium (DBDC) is leading the first major effort to improve dietary assessment through the discovery and validation of biomarkers for foods commonly consumed in the United States diet. To achieve this goal, a 3-phase approach will be implemented to identify, evaluate, and validate food biomarkers. In phase 1, 3 controlled feeding trial designs will be implemented by administering test foods in prespecified amounts to healthy participants, followed by metabolomic profiling of blood and urine specimens collected during the feeding trials to identify candidate compounds. Data from these studies will characterize the pharmacokinetic parameters of candidate biomarkers associated with specific foods. In phase 2, the ability of candidate biomarkers to identify individuals eating the biomarker-associated foods will be evaluated using controlled feeding studies of various dietary patterns. In phase 3, the validity of candidate biomarkers to predict recent and habitual consumption of specific test foods will be evaluated in independent observational settings. Data generated during all study phases will be archived in a publicly accessible database as a resource for the research community. The DBDC aims to significantly expand the list of validated biomarkers of intake for foods consumed in the United States diet, which can help advance understanding of how diet influences human health. This manuscript discusses the DBDC’s organizational infrastructure, study design, laboratory methods, and strategies for dietary biomarker discovery and validation. Trial registration number: This trial was registered at Phase 1 Seattle Dietary Biomarkers Development Center (P1-SDBDC) as NCT05580653, at Fruit and Vegetable Biomarker Discovery (UCD-DBDC) as NCT05621863, and at Dietary Biomarkers Intervention Core as NCT05616585.
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spelling doaj-art-0487d64cda1744408b0f5e38e8762e792025-08-20T01:54:21ZengElsevierCurrent Developments in Nutrition2475-29912025-05-019510743510.1016/j.cdnut.2025.107435The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision NutritionHrishikesh Chakraborty0Qi Sun1Shilpa N Bhupathiraju2Jeannette M Schenk3Darya O Mishchuk4James R Bain5Xuan He6Jianghao Sun7James Harnly8William Simmons9Daniel Raftery10Liming Liang11John W Newman12Oliver Fiehn13Clary B Clish14Johanna W Lampe15Brian J Bennett16Sandi L Navarro17Ying Wang18Cheng Zheng19Yasmin Mossavar-Rahmani20Marjorie L McCullough21Ying Huang22Ali Shojaie23Wentao Zhu24Danijel Djukovic25Frank Sacks26Jonathan Williams27Francene M Steinberg28Sean H Adams29Frank B Hu30Marian L Neuhouser31Carolyn M Slupsky32Padma Maruvada33Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, United States; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States; Corresponding author.Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United StatesDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United StatesDepartment of Food Science and Technology, University of California Davis, Davis, CA, United StatesDepartment of Medicine, Duke University School of Medicine, Durham, NC, United StatesDepartment of Food Science and Technology, University of California Davis, Davis, CA, United States; Department of Nutrition, University of California Davis, Davis, CA, United StatesMethods and Application of Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, United StatesMethods and Application of Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, United StatesDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United States; Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, United StatesDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United StatesDepartment of Nutrition, University of California Davis, Davis, CA, United States; Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Davis, CA, United States; West Coast Metabolomics Center, UC Davis Genome Center, University of California Davis, Davis, CA, United StatesWest Coast Metabolomics Center, UC Davis Genome Center, University of California Davis, Davis, CA, United States; Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, United StatesBroad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United StatesDepartment of Nutrition, University of California Davis, Davis, CA, United States; Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Davis, CA, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United StatesAmerican Cancer Society, Atlanta, GA, United StatesDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, United StatesDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United StatesAmerican Cancer Society, Atlanta, GA, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United StatesDepartment of Biostatistics, University of Washington, Seattle, WA, United StatesDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, United StatesDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, United StatesDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United StatesDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Nutrition, University of California Davis, Davis, CA, United StatesDepartment of Surgery, University of California Davis School of Medicine, Sacramento, CA, United States; Center for Alimentary and Metabolic Science, University of California Davis, Sacramento, CA, United StatesDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United States; Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, United StatesPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, United StatesDepartment of Food Science and Technology, University of California Davis, Davis, CA, United States; Department of Nutrition, University of California Davis, Davis, CA, United StatesDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, United States National Institutes of Health, Bethesda, MD, United StatesDiet is a complex exposure that affects health across the lifespan. Objective biomarkers that can reliably reflect intake of nutrients, foods, and dietary patterns with sufficient accuracy are an important tool for assessing associations of diet with health outcomes. Advances in metabolomics, coupled with feeding trials and high-dimensional bioinformatics analyses, pave the way for discovering compounds that can serve as sensitive and specific biomarkers of dietary exposures. The Dietary Biomarkers Development Consortium (DBDC) is leading the first major effort to improve dietary assessment through the discovery and validation of biomarkers for foods commonly consumed in the United States diet. To achieve this goal, a 3-phase approach will be implemented to identify, evaluate, and validate food biomarkers. In phase 1, 3 controlled feeding trial designs will be implemented by administering test foods in prespecified amounts to healthy participants, followed by metabolomic profiling of blood and urine specimens collected during the feeding trials to identify candidate compounds. Data from these studies will characterize the pharmacokinetic parameters of candidate biomarkers associated with specific foods. In phase 2, the ability of candidate biomarkers to identify individuals eating the biomarker-associated foods will be evaluated using controlled feeding studies of various dietary patterns. In phase 3, the validity of candidate biomarkers to predict recent and habitual consumption of specific test foods will be evaluated in independent observational settings. Data generated during all study phases will be archived in a publicly accessible database as a resource for the research community. The DBDC aims to significantly expand the list of validated biomarkers of intake for foods consumed in the United States diet, which can help advance understanding of how diet influences human health. This manuscript discusses the DBDC’s organizational infrastructure, study design, laboratory methods, and strategies for dietary biomarker discovery and validation. Trial registration number: This trial was registered at Phase 1 Seattle Dietary Biomarkers Development Center (P1-SDBDC) as NCT05580653, at Fruit and Vegetable Biomarker Discovery (UCD-DBDC) as NCT05621863, and at Dietary Biomarkers Intervention Core as NCT05616585.http://www.sciencedirect.com/science/article/pii/S2475299125028951dietary biomarkersdietary exposuresmetabolomicsfood chemistryconsortium
spellingShingle Hrishikesh Chakraborty
Qi Sun
Shilpa N Bhupathiraju
Jeannette M Schenk
Darya O Mishchuk
James R Bain
Xuan He
Jianghao Sun
James Harnly
William Simmons
Daniel Raftery
Liming Liang
John W Newman
Oliver Fiehn
Clary B Clish
Johanna W Lampe
Brian J Bennett
Sandi L Navarro
Ying Wang
Cheng Zheng
Yasmin Mossavar-Rahmani
Marjorie L McCullough
Ying Huang
Ali Shojaie
Wentao Zhu
Danijel Djukovic
Frank Sacks
Jonathan Williams
Francene M Steinberg
Sean H Adams
Frank B Hu
Marian L Neuhouser
Carolyn M Slupsky
Padma Maruvada
The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
Current Developments in Nutrition
dietary biomarkers
dietary exposures
metabolomics
food chemistry
consortium
title The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
title_full The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
title_fullStr The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
title_full_unstemmed The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
title_short The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
title_sort dietary biomarkers development consortium an initiative for discovery and validation of dietary biomarkers for precision nutrition
topic dietary biomarkers
dietary exposures
metabolomics
food chemistry
consortium
url http://www.sciencedirect.com/science/article/pii/S2475299125028951
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