Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline
Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2011/201617 |
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| author | Alexander Yaw Debrah Sabine Mand Yeboah Marfo-Debrekyei Linda Batsa Anna Albers Sabine Specht Ute Klarmann Kenneth Pfarr Ohene Adjei Achim Hoerauf |
| author_facet | Alexander Yaw Debrah Sabine Mand Yeboah Marfo-Debrekyei Linda Batsa Anna Albers Sabine Specht Ute Klarmann Kenneth Pfarr Ohene Adjei Achim Hoerauf |
| author_sort | Alexander Yaw Debrah |
| collection | DOAJ |
| description | Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti. |
| format | Article |
| id | doaj-art-0487b858f50043548e7ef8ee024c1efe |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-0487b858f50043548e7ef8ee024c1efe2025-02-03T01:10:54ZengWileyJournal of Parasitology Research2090-00232090-00312011-01-01201110.1155/2011/201617201617Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus DoxycyclineAlexander Yaw Debrah0Sabine Mand1Yeboah Marfo-Debrekyei2Linda Batsa3Anna Albers4Sabine Specht5Ute Klarmann6Kenneth Pfarr7Ohene Adjei8Achim Hoerauf9Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, GhanaInstitute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Straβe 25, D-53105 Bonn, GermanyKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, GhanaKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, GhanaInstitute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Straβe 25, D-53105 Bonn, GermanyInstitute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Straβe 25, D-53105 Bonn, GermanyInstitute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Straβe 25, D-53105 Bonn, GermanyInstitute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Straβe 25, D-53105 Bonn, GermanySchool of Medical Sciences, Kwame Nkrumah University of Science and Technology, UPO, PMB, Kumasi, GhanaInstitute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Straβe 25, D-53105 Bonn, GermanyInfection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti.http://dx.doi.org/10.1155/2011/201617 |
| spellingShingle | Alexander Yaw Debrah Sabine Mand Yeboah Marfo-Debrekyei Linda Batsa Anna Albers Sabine Specht Ute Klarmann Kenneth Pfarr Ohene Adjei Achim Hoerauf Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline Journal of Parasitology Research |
| title | Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline |
| title_full | Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline |
| title_fullStr | Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline |
| title_full_unstemmed | Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline |
| title_short | Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline |
| title_sort | macrofilaricidal activity in wuchereria bancrofti after 2 weeks treatment with a combination of rifampicin plus doxycycline |
| url | http://dx.doi.org/10.1155/2011/201617 |
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