The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study

Introduction: To investigate whether changes in optical coherence tomography angiography (OCTA) values can predict progression in the visual field (VF) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. Methods: All patients in the glaucoma outpatient clinic of SBU Gulhane M...

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Main Authors: Suleyman Demir, Mehmet Talay Koylu, Alper Can Yılmaz
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Photodiagnosis and Photodynamic Therapy
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Online Access:http://www.sciencedirect.com/science/article/pii/S1572100024004198
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author Suleyman Demir
Mehmet Talay Koylu
Alper Can Yılmaz
author_facet Suleyman Demir
Mehmet Talay Koylu
Alper Can Yılmaz
author_sort Suleyman Demir
collection DOAJ
description Introduction: To investigate whether changes in optical coherence tomography angiography (OCTA) values can predict progression in the visual field (VF) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. Methods: All patients in the glaucoma outpatient clinic of SBU Gulhane Medicine Faculty between 2021 and 2023 underwent RNFL, 24:2 VF, and simultaneous peripapillary OCTA. 130 eyes that progressed were included in the study. Thinning of more than 5 μ in any quadrant in the RNFL or a decrease of more than 1 dB in the MD value in the visual field within 6 months was accepted as a progression criterion. The ability of changes in OCTA thickness values and OCTA radial peripapillary capillary plexus (RPCP) analysis to predict progression in RNFL and VF was prospectively investigated. Results: The mean age of the patients was 66.9 ± 11.8 years. There was progression in VF in 70 eyes and RNFL in 89 eyes between baseline and 6-month controls. The change in OCTA thickness values had insufficient ability to predict the progression of RNFL in the superior, inferior, nasal, temporal and total quadrants (p = 0.55, 0.40, 0.84, 0.91, 0.39, respectively). The changes in OCTA thickness values failed to predict VF MD progression in the superior, inferior,nasal,temporal,and total quadrants (p = 0.40, 0.11, 0.24, 0.44, 0.10, respectively). The changes in OCTA RPCP values ​​did not show superiority in the ability to predict RNFL progression in superior, inferior, nasal, temporal, and total quadrants (p = 0.21, 0.53, 0.39, 0.39, 0.29, respectively). The changes in OCTA RPCP values ​​did not show superiority in the ability to predict VF progression in superior, inferior, nasal, temporal, and total quadrants (p = 0.96, 0.29, 0.77, 0.42, 0.21, respectively). Conclusion: Although OCTA is a non-invasive imaging test whose use and popularity have been increasing in recent years, our study could not show superiority compared to RNFL and VF tests in demonstrating glaucoma progression.
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spelling doaj-art-0485bcbd3aef49a6a9f79a6aa55774d22024-12-13T10:56:10ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-12-0150104382The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective studySuleyman Demir0Mehmet Talay Koylu1Alper Can Yılmaz2Corresponding author at: University of Health Sciences Gulhane Faculty of Medicine, Department of Ophthalmology, Emrah Mahallesi, Gen. Dr. Tevfik Saglam Cd No:11, 06010, Kecioren, Ankara Turkey.; University of Health Sciences Gulhane Faculty of Medicine, Department of Ophthalmology, Ankara, TurkeyUniversity of Health Sciences Gulhane Faculty of Medicine, Department of Ophthalmology, Ankara, TurkeyUniversity of Health Sciences Gulhane Faculty of Medicine, Department of Ophthalmology, Ankara, TurkeyIntroduction: To investigate whether changes in optical coherence tomography angiography (OCTA) values can predict progression in the visual field (VF) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. Methods: All patients in the glaucoma outpatient clinic of SBU Gulhane Medicine Faculty between 2021 and 2023 underwent RNFL, 24:2 VF, and simultaneous peripapillary OCTA. 130 eyes that progressed were included in the study. Thinning of more than 5 μ in any quadrant in the RNFL or a decrease of more than 1 dB in the MD value in the visual field within 6 months was accepted as a progression criterion. The ability of changes in OCTA thickness values and OCTA radial peripapillary capillary plexus (RPCP) analysis to predict progression in RNFL and VF was prospectively investigated. Results: The mean age of the patients was 66.9 ± 11.8 years. There was progression in VF in 70 eyes and RNFL in 89 eyes between baseline and 6-month controls. The change in OCTA thickness values had insufficient ability to predict the progression of RNFL in the superior, inferior, nasal, temporal and total quadrants (p = 0.55, 0.40, 0.84, 0.91, 0.39, respectively). The changes in OCTA thickness values failed to predict VF MD progression in the superior, inferior,nasal,temporal,and total quadrants (p = 0.40, 0.11, 0.24, 0.44, 0.10, respectively). The changes in OCTA RPCP values ​​did not show superiority in the ability to predict RNFL progression in superior, inferior, nasal, temporal, and total quadrants (p = 0.21, 0.53, 0.39, 0.39, 0.29, respectively). The changes in OCTA RPCP values ​​did not show superiority in the ability to predict VF progression in superior, inferior, nasal, temporal, and total quadrants (p = 0.96, 0.29, 0.77, 0.42, 0.21, respectively). Conclusion: Although OCTA is a non-invasive imaging test whose use and popularity have been increasing in recent years, our study could not show superiority compared to RNFL and VF tests in demonstrating glaucoma progression.http://www.sciencedirect.com/science/article/pii/S1572100024004198GlaucomaGlaucoma progressionRNFLVisual fieldOCTA
spellingShingle Suleyman Demir
Mehmet Talay Koylu
Alper Can Yılmaz
The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study
Photodiagnosis and Photodynamic Therapy
Glaucoma
Glaucoma progression
RNFL
Visual field
OCTA
title The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study
title_full The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study
title_fullStr The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study
title_full_unstemmed The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study
title_short The ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression: A prospective study
title_sort ability of changes in oct angiography values to predict visual field and retinal nerve layer tomography progression in patients with glaucoma progression a prospective study
topic Glaucoma
Glaucoma progression
RNFL
Visual field
OCTA
url http://www.sciencedirect.com/science/article/pii/S1572100024004198
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