Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report
Some type 1 diabetes mellitus (T1DM) patients develop features of insulin resistance, typically seen in type 2 diabetes mellitus, leading to a condition termed hybrid diabetes mellitus (HDM). We present a case of a 30-year-old female diagnosed with HDM and cardiovascular complications. She had a his...
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Journal of Diabetology |
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| Online Access: | https://journals.lww.com/jodb/fulltext/2024/15040/complex_of_hybrid_diabetes_mellitus_with_severe.17.aspx |
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| author | Pranjali Shah |
| author_facet | Pranjali Shah |
| author_sort | Pranjali Shah |
| collection | DOAJ |
| description | Some type 1 diabetes mellitus (T1DM) patients develop features of insulin resistance, typically seen in type 2 diabetes mellitus, leading to a condition termed hybrid diabetes mellitus (HDM). We present a case of a 30-year-old female diagnosed with HDM and cardiovascular complications. She had a history of T1DM from the age of 7 years and presented with acute right-sided limb weakness. She had comorbidities, including hypertension, polycystic ovarian syndrome, hypothyroidism, and a high Body Mass Index (37 kg/m2). Initial evaluations revealed elevated blood pressure, pulse rate, thrombocytosis, homocysteine level, and hemoglobin A1c. Magnetic resonance imaging showed a completely blocked carotid artery and cardiological assessments indicated mild left ventricular hypertrophy and diastolic dysfunction. Glutamic acid decarboxylase antibodies were positive, and C-peptide was absent, confirming T1DM with insulin resistance HDM. Treatment involved anticoagulants, antiplatelets, statins, and supportive care. The patient showed significant clinical improvement, although surgery was not viable due to completely blocked vessels. |
| format | Article |
| id | doaj-art-047bcb5c8b534be3a20ba702da174bcc |
| institution | OA Journals |
| issn | 2078-7685 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Diabetology |
| spelling | doaj-art-047bcb5c8b534be3a20ba702da174bcc2025-08-20T02:35:44ZengWolters Kluwer Medknow PublicationsJournal of Diabetology2078-76852024-10-0115444044210.4103/jod.jod_114_24Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case ReportPranjali ShahSome type 1 diabetes mellitus (T1DM) patients develop features of insulin resistance, typically seen in type 2 diabetes mellitus, leading to a condition termed hybrid diabetes mellitus (HDM). We present a case of a 30-year-old female diagnosed with HDM and cardiovascular complications. She had a history of T1DM from the age of 7 years and presented with acute right-sided limb weakness. She had comorbidities, including hypertension, polycystic ovarian syndrome, hypothyroidism, and a high Body Mass Index (37 kg/m2). Initial evaluations revealed elevated blood pressure, pulse rate, thrombocytosis, homocysteine level, and hemoglobin A1c. Magnetic resonance imaging showed a completely blocked carotid artery and cardiological assessments indicated mild left ventricular hypertrophy and diastolic dysfunction. Glutamic acid decarboxylase antibodies were positive, and C-peptide was absent, confirming T1DM with insulin resistance HDM. Treatment involved anticoagulants, antiplatelets, statins, and supportive care. The patient showed significant clinical improvement, although surgery was not viable due to completely blocked vessels.https://journals.lww.com/jodb/fulltext/2024/15040/complex_of_hybrid_diabetes_mellitus_with_severe.17.aspxhybrid diabetes mellitus; internal carotid artery occlusion; middle cerebral artery infarct; mri brain; two-dimensional echocardiography |
| spellingShingle | Pranjali Shah Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report Journal of Diabetology hybrid diabetes mellitus; internal carotid artery occlusion; middle cerebral artery infarct; mri brain; two-dimensional echocardiography |
| title | Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report |
| title_full | Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report |
| title_fullStr | Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report |
| title_full_unstemmed | Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report |
| title_short | Complex of Hybrid Diabetes Mellitus With Severe Insulin Resistance and Cerebrovascular Complications: A Case Report |
| title_sort | complex of hybrid diabetes mellitus with severe insulin resistance and cerebrovascular complications a case report |
| topic | hybrid diabetes mellitus; internal carotid artery occlusion; middle cerebral artery infarct; mri brain; two-dimensional echocardiography |
| url | https://journals.lww.com/jodb/fulltext/2024/15040/complex_of_hybrid_diabetes_mellitus_with_severe.17.aspx |
| work_keys_str_mv | AT pranjalishah complexofhybriddiabetesmellituswithsevereinsulinresistanceandcerebrovascularcomplicationsacasereport |