Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups

Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups

Abstract Uterine leiomyomata or fibroids are highly heritable, common, and benign tumors of the uterus with poorly understood etiology. Previous GWAS have reported 72 associated genes but included limited numbers of non-European individuals. Here, we identify 11 novel genes associated with fibroids...

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Main Authors: Jeewoo Kim, Ariel Williams, Hannah Noh, Elizabeth A. Jasper, Sarah H. Jones, James A. Jaworski, Megan M. Shuey, Edward A. Ruiz-Narváez, Lauren A. Wise, Julie R. Palmer, John Connolly, Jacob M. Keaton, Joshua C. Denny, Atlas Khan, Mohammad A. Abbass, Laura J. Rasmussen-Torvik, Leah C. Kottyan, Purnima Madhivanan, Karl Krupp, Wei-Qi Wei, Todd L. Edwards, Digna R. Velez Edwards, Jacklyn N. Hellwege
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57483-5
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