Activation and Regulation of Cellular Eicosanoid Biosynthesis
There is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a receptor-mediated fashion. These mediators are...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.180 |
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| _version_ | 1832554883377528832 |
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| author | Thomas G. Brock Marc Peters-Golden |
| author_facet | Thomas G. Brock Marc Peters-Golden |
| author_sort | Thomas G. Brock |
| collection | DOAJ |
| description | There is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a receptor-mediated fashion. These mediators are related in that they are all derived from one polyunsaturated fatty acid, arachidonic acid. However, the various eicosanoids are synthesized by a wide variety of cell types by distinct enzymatic pathways, and have diverse roles in immunity and inflammation. In this review, the major pathways involved in the synthesis of eicosanoids, as well as key points of regulation, are presented. |
| format | Article |
| id | doaj-art-047343693cef453b87e7259da8978000 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-047343693cef453b87e7259da89780002025-02-03T05:50:15ZengWileyThe Scientific World Journal1537-744X2007-01-0171273128410.1100/tsw.2007.180Activation and Regulation of Cellular Eicosanoid BiosynthesisThomas G. Brock0Marc Peters-Golden1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USADivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USAThere is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a receptor-mediated fashion. These mediators are related in that they are all derived from one polyunsaturated fatty acid, arachidonic acid. However, the various eicosanoids are synthesized by a wide variety of cell types by distinct enzymatic pathways, and have diverse roles in immunity and inflammation. In this review, the major pathways involved in the synthesis of eicosanoids, as well as key points of regulation, are presented.http://dx.doi.org/10.1100/tsw.2007.180 |
| spellingShingle | Thomas G. Brock Marc Peters-Golden Activation and Regulation of Cellular Eicosanoid Biosynthesis The Scientific World Journal |
| title | Activation and Regulation of Cellular Eicosanoid Biosynthesis |
| title_full | Activation and Regulation of Cellular Eicosanoid Biosynthesis |
| title_fullStr | Activation and Regulation of Cellular Eicosanoid Biosynthesis |
| title_full_unstemmed | Activation and Regulation of Cellular Eicosanoid Biosynthesis |
| title_short | Activation and Regulation of Cellular Eicosanoid Biosynthesis |
| title_sort | activation and regulation of cellular eicosanoid biosynthesis |
| url | http://dx.doi.org/10.1100/tsw.2007.180 |
| work_keys_str_mv | AT thomasgbrock activationandregulationofcellulareicosanoidbiosynthesis AT marcpetersgolden activationandregulationofcellulareicosanoidbiosynthesis |