Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024
BackgroundDespite the availability of vaccination and early treatment, cervical cancer remains a significant public health concern globally, particularly in Sub-Saharan Africa, where access to screening and treatment is often limited.MethodsIn this study, researchers conducted a survey of four inter...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1491840/full |
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| author | Tadele Emagneneh Chalie Mulugeta Betelhem Ejigu Abebaw Alamrew Aynalem Yetwale Hiwot Sefineh Fenta Feleke |
| author_facet | Tadele Emagneneh Chalie Mulugeta Betelhem Ejigu Abebaw Alamrew Aynalem Yetwale Hiwot Sefineh Fenta Feleke |
| author_sort | Tadele Emagneneh |
| collection | DOAJ |
| description | BackgroundDespite the availability of vaccination and early treatment, cervical cancer remains a significant public health concern globally, particularly in Sub-Saharan Africa, where access to screening and treatment is often limited.MethodsIn this study, researchers conducted a survey of four international databases—Medline/PubMed, Scopus, Web of Science, and Henare—along with Google Scholar to search for gray literature. The keywords used for searching the international databases included “Uterine Cervical Neoplasms [Mesh],” “Survival OR Survival Analysis OR Survival Rate,” and “Sub-Saharan countries” (including the names of specific countries). Six researchers independently screened and extracted data from the articles. All studies published in English were included without restriction and assessed for quality using the adapted Newcastle–Ottawa Scale for cohort and cross-sectional studies. The results of this systematic review were reported in accordance with the PRISMA checklist.ResultsOut of the 2,180 articles initially identified, 23 were deemed eligible and reported on the survival status of patients with cervical cancer in Sub-Saharan Africa. This study assessed the multi-year survival rates (1, 2, 3, 4, and 5 years) of patients with cervical cancer. Based on the random-effects model, the overall pooled 1-year survival was 65.0% [95% confidence interval (CI), 52–78] with I² = 99.31 and p-value < 0.001. The 2-year survival rate was 60% (95% CI, 46–74) with I² = 99.12 and p-value < 0.001, the 3-year survival was 48% (95% CI, 35–62) with I² = 98.45 and p-value < 0.001, the 4-year survival was 42.9% (95% CI, 32.7–53.1) with I² = 96.80 and p-value < 0.001, and the 5-year survival was 35% (95% CI, 27–44) with I² = 98.74 and p-value < 0.001.ConclusionsThis systematic review and meta-analysis found that the survival rates for patients with cervical cancer in Sub-Saharan Africa are much lower than the global averages. The results show that the 5-year survival rate can be as low as 35%, highlighting serious challenges in managing cervical cancer in this region. To address this issue, collaboration among governments, healthcare providers, and international organizations is essential to enhance the availability and quality of care. Future research should focus on developing effective early detection and treatment strategies and monitoring long-term survival outcomes. |
| format | Article |
| id | doaj-art-04728421f56545418dd815b40fc8b2fe |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-04728421f56545418dd815b40fc8b2fe2025-01-07T05:23:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14918401491840Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024Tadele Emagneneh0Chalie Mulugeta1Betelhem Ejigu2Abebaw Alamrew3Aynalem Yetwale Hiwot4Sefineh Fenta Feleke5Department of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Midwifery, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Public Health, College of Health Sciences, Woldia University, Woldia, EthiopiaBackgroundDespite the availability of vaccination and early treatment, cervical cancer remains a significant public health concern globally, particularly in Sub-Saharan Africa, where access to screening and treatment is often limited.MethodsIn this study, researchers conducted a survey of four international databases—Medline/PubMed, Scopus, Web of Science, and Henare—along with Google Scholar to search for gray literature. The keywords used for searching the international databases included “Uterine Cervical Neoplasms [Mesh],” “Survival OR Survival Analysis OR Survival Rate,” and “Sub-Saharan countries” (including the names of specific countries). Six researchers independently screened and extracted data from the articles. All studies published in English were included without restriction and assessed for quality using the adapted Newcastle–Ottawa Scale for cohort and cross-sectional studies. The results of this systematic review were reported in accordance with the PRISMA checklist.ResultsOut of the 2,180 articles initially identified, 23 were deemed eligible and reported on the survival status of patients with cervical cancer in Sub-Saharan Africa. This study assessed the multi-year survival rates (1, 2, 3, 4, and 5 years) of patients with cervical cancer. Based on the random-effects model, the overall pooled 1-year survival was 65.0% [95% confidence interval (CI), 52–78] with I² = 99.31 and p-value < 0.001. The 2-year survival rate was 60% (95% CI, 46–74) with I² = 99.12 and p-value < 0.001, the 3-year survival was 48% (95% CI, 35–62) with I² = 98.45 and p-value < 0.001, the 4-year survival was 42.9% (95% CI, 32.7–53.1) with I² = 96.80 and p-value < 0.001, and the 5-year survival was 35% (95% CI, 27–44) with I² = 98.74 and p-value < 0.001.ConclusionsThis systematic review and meta-analysis found that the survival rates for patients with cervical cancer in Sub-Saharan Africa are much lower than the global averages. The results show that the 5-year survival rate can be as low as 35%, highlighting serious challenges in managing cervical cancer in this region. To address this issue, collaboration among governments, healthcare providers, and international organizations is essential to enhance the availability and quality of care. Future research should focus on developing effective early detection and treatment strategies and monitoring long-term survival outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2024.1491840/fullcervical cancersurvival statusSub-Saharan Africasystematic reviewmeta-analysis |
| spellingShingle | Tadele Emagneneh Chalie Mulugeta Betelhem Ejigu Abebaw Alamrew Aynalem Yetwale Hiwot Sefineh Fenta Feleke Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 Frontiers in Oncology cervical cancer survival status Sub-Saharan Africa systematic review meta-analysis |
| title | Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 |
| title_full | Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 |
| title_fullStr | Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 |
| title_full_unstemmed | Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 |
| title_short | Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024 |
| title_sort | survival status of women with cervical cancer in sub saharan africa a systematic review and meta analysis 2024 |
| topic | cervical cancer survival status Sub-Saharan Africa systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1491840/full |
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