Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction
Background: Heart failure (HF) following acute myocardial infarction (AMI) is characterized by high mortality and disability rates, which highlights the need of timely and effective revascularization. Recent studies suggested the potential predictivity of biomarkers NT-proBNP, cTNT, PLR, NLR, and GD...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501069G.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832096558659665920 |
|---|---|
| author | Guihong Rong Xiao Wang Xinling Qin Yanxia Wang Meilian Quan Chunfeng Xi |
| author_facet | Guihong Rong Xiao Wang Xinling Qin Yanxia Wang Meilian Quan Chunfeng Xi |
| author_sort | Guihong Rong |
| collection | DOAJ |
| description | Background: Heart failure (HF) following acute myocardial infarction (AMI) is characterized by high mortality and disability rates, which highlights the need of timely and effective revascularization. Recent studies suggested the potential predictivity of biomarkers NT-proBNP, cTNT, PLR, NLR, and GDF-15 in cardiovascular events, but their value in HF patients post-AMI still require further verification. Therefore, the present study aimed to identify potent biomarkers for prognosticating the development of HF subsequent to AMI, and to devise early interception and therapeutic strategies. Methods: A total of 170 patients with AMI were enrolled in this study, including 44 patients with post-AMI HF and 126 patients with post-AMI non-HF. We measured the serum biomarkers NT-proBNP, cTNT, PLR, NLR, and GDF-15 in all patients using enzyme-linked immunosorbent assay (ELISA). Subsequently, we performed t-tests to assess the predictive value of these biomarkers for post-AMI HF. Results: In the group of HF patients, cTNT, NT-proBNP, GDF-15 and NLR was significantly higher than in the group without HF, but PLR was not. The AUC of NLR to predict HF after AMI was 0.632 (95%CI: 0.542-0.723), P=0.010, with a cut-off value of (3.86×109)/L, GDF-15 was 0.661 (95%CI: 0.560-0.763), P=0.002, with a cutoff value of 1.35 ng/mL, and NT-proBNP was 0.82 (95%CI: 0.723-0.876), P<0.001, with a cut-off value of 1444 pg/mL. Conclusions: In five biomarkers, there is predictive value in NT-proBNP, NLR, GDF-15 for patients with HF after AMI. |
| format | Article |
| id | doaj-art-046f04bbdb5f41b5a628e5bfe13f6454 |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-046f04bbdb5f41b5a628e5bfe13f64542025-02-05T13:11:23ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-01441697610.5937/jomb0-507411452-82582501069GPlasma biomarkers for predicting heart failure in patients with acute myocardial infarctionGuihong Rong0Xiao Wang1Xinling Qin2Yanxia Wang3Meilian Quan4Chunfeng Xi5Affiliated Hospital of Guilin Medical University, Department of Clinical Laboratory, Guilin, ChinaAffiliated Hospital of Guilin Medical University, Department of Clinical Laboratory, Guilin, ChinaAffiliated Hospital of Guilin Medical University, Department of Clinical Laboratory, Guilin, ChinaAffiliated Hospital of Guilin Medical University, Department of Clinical Laboratory, Guilin, ChinaAffiliated Hospital of Guilin Medical University, Department of Clinical Laboratory, Guilin, ChinaAffiliated Hospital of Guilin Medical University, Department of Clinical Laboratory, Guilin, ChinaBackground: Heart failure (HF) following acute myocardial infarction (AMI) is characterized by high mortality and disability rates, which highlights the need of timely and effective revascularization. Recent studies suggested the potential predictivity of biomarkers NT-proBNP, cTNT, PLR, NLR, and GDF-15 in cardiovascular events, but their value in HF patients post-AMI still require further verification. Therefore, the present study aimed to identify potent biomarkers for prognosticating the development of HF subsequent to AMI, and to devise early interception and therapeutic strategies. Methods: A total of 170 patients with AMI were enrolled in this study, including 44 patients with post-AMI HF and 126 patients with post-AMI non-HF. We measured the serum biomarkers NT-proBNP, cTNT, PLR, NLR, and GDF-15 in all patients using enzyme-linked immunosorbent assay (ELISA). Subsequently, we performed t-tests to assess the predictive value of these biomarkers for post-AMI HF. Results: In the group of HF patients, cTNT, NT-proBNP, GDF-15 and NLR was significantly higher than in the group without HF, but PLR was not. The AUC of NLR to predict HF after AMI was 0.632 (95%CI: 0.542-0.723), P=0.010, with a cut-off value of (3.86×109)/L, GDF-15 was 0.661 (95%CI: 0.560-0.763), P=0.002, with a cutoff value of 1.35 ng/mL, and NT-proBNP was 0.82 (95%CI: 0.723-0.876), P<0.001, with a cut-off value of 1444 pg/mL. Conclusions: In five biomarkers, there is predictive value in NT-proBNP, NLR, GDF-15 for patients with HF after AMI.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501069G.pdfheart failureacute myocardial infarctiongdf-15nt-probnp |
| spellingShingle | Guihong Rong Xiao Wang Xinling Qin Yanxia Wang Meilian Quan Chunfeng Xi Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction Journal of Medical Biochemistry heart failure acute myocardial infarction gdf-15 nt-probnp |
| title | Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction |
| title_full | Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction |
| title_fullStr | Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction |
| title_full_unstemmed | Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction |
| title_short | Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction |
| title_sort | plasma biomarkers for predicting heart failure in patients with acute myocardial infarction |
| topic | heart failure acute myocardial infarction gdf-15 nt-probnp |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501069G.pdf |
| work_keys_str_mv | AT guihongrong plasmabiomarkersforpredictingheartfailureinpatientswithacutemyocardialinfarction AT xiaowang plasmabiomarkersforpredictingheartfailureinpatientswithacutemyocardialinfarction AT xinlingqin plasmabiomarkersforpredictingheartfailureinpatientswithacutemyocardialinfarction AT yanxiawang plasmabiomarkersforpredictingheartfailureinpatientswithacutemyocardialinfarction AT meilianquan plasmabiomarkersforpredictingheartfailureinpatientswithacutemyocardialinfarction AT chunfengxi plasmabiomarkersforpredictingheartfailureinpatientswithacutemyocardialinfarction |