From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging
This article systematically elaborates the central role of inflammatory response and oxidative stress in osteoporosis (OP) and cartilage injury, and reveals the molecular mechanism by which the two damage bone homeostasis through NF-κB, RANKL and other signaling pathways. Studies have shown that pla...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1634580/full |
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| author | Qi Li Xiumei Zhao Anning Wang Tingting Hang Jianpeng Zhao Shengkai Zhang Lingfeng Zeng Weiguo Wang Weiguo Wang |
| author_facet | Qi Li Xiumei Zhao Anning Wang Tingting Hang Jianpeng Zhao Shengkai Zhang Lingfeng Zeng Weiguo Wang Weiguo Wang |
| author_sort | Qi Li |
| collection | DOAJ |
| description | This article systematically elaborates the central role of inflammatory response and oxidative stress in osteoporosis (OP) and cartilage injury, and reveals the molecular mechanism by which the two damage bone homeostasis through NF-κB, RANKL and other signaling pathways. Studies have shown that plant natural products (such as hesperidin, curcumin, Epimedin B, etc.) can improve bone metabolism imbalance and delay the process of bone aging by regulating inflammatory factors (TNF-α, IL-1β) and antioxidant pathways (Nrf2/HO-1). Osteoporosis and cartilage damage promote each other to form a vicious cycle, and the intervention of plant active ingredients can target this common pathological process. Based on the current evidence, the strategy of combining anti-inflammation, anti-oxidation and mechanical regulation may provide a new direction for the prevention and treatment of bone aging-related diseases. |
| format | Article |
| id | doaj-art-046d2d235bcc447a98f6f332d1e02e35 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-046d2d235bcc447a98f6f332d1e02e352025-08-20T03:28:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.16345801634580From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone agingQi Li0Xiumei Zhao1Anning Wang2Tingting Hang3Jianpeng Zhao4Shengkai Zhang5Lingfeng Zeng6Weiguo Wang7Weiguo Wang8Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, Jinan, ChinaSecond Department of Clinical Psychology, Shandong Mental Health Center, Shandong, Jinan, ChinaFirst School of Clinical Medicine, Shandong Traditional Chinese Medicine University, Shandong, Jinan, ChinaFirst School of Clinical Medicine, Shandong Traditional Chinese Medicine University, Shandong, Jinan, ChinaFirst School of Clinical Medicine, Shandong Traditional Chinese Medicine University, Shandong, Jinan, ChinaFirst School of Clinical Medicine, Shandong Traditional Chinese Medicine University, Shandong, Jinan, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, Jinan, ChinaFirst School of Clinical Medicine, Shandong Traditional Chinese Medicine University, Shandong, Jinan, ChinaThis article systematically elaborates the central role of inflammatory response and oxidative stress in osteoporosis (OP) and cartilage injury, and reveals the molecular mechanism by which the two damage bone homeostasis through NF-κB, RANKL and other signaling pathways. Studies have shown that plant natural products (such as hesperidin, curcumin, Epimedin B, etc.) can improve bone metabolism imbalance and delay the process of bone aging by regulating inflammatory factors (TNF-α, IL-1β) and antioxidant pathways (Nrf2/HO-1). Osteoporosis and cartilage damage promote each other to form a vicious cycle, and the intervention of plant active ingredients can target this common pathological process. Based on the current evidence, the strategy of combining anti-inflammation, anti-oxidation and mechanical regulation may provide a new direction for the prevention and treatment of bone aging-related diseases.https://www.frontiersin.org/articles/10.3389/fendo.2025.1634580/fullosteoporosisbone agingcartilage injuryinflammatory responseoxidative stresssignaling pathways |
| spellingShingle | Qi Li Xiumei Zhao Anning Wang Tingting Hang Jianpeng Zhao Shengkai Zhang Lingfeng Zeng Weiguo Wang Weiguo Wang From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging Frontiers in Endocrinology osteoporosis bone aging cartilage injury inflammatory response oxidative stress signaling pathways |
| title | From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging |
| title_full | From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging |
| title_fullStr | From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging |
| title_full_unstemmed | From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging |
| title_short | From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging |
| title_sort | from molecular mechanism to plant intervention the bidirectional regulation of inflammation and oxidative stress in bone aging |
| topic | osteoporosis bone aging cartilage injury inflammatory response oxidative stress signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1634580/full |
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