M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

Abstract The dysregulation of the M1/M2 macrophage balance plays a pivotal role in autoimmune diseases. However, the interplay between microRNAs (miRNAs) and N6‐methyladenosine (m6A) modulation in regulating this balance remains poorly understood. Here, a significant reduction in miR‐31‐5p levels is...

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Bibliographic Details
Main Authors: Lu Zhao, Xuejia Li, Min Gao, Lin Liu, Binyun Ma, Xun Liu, Jiachen Zhang, Ruoxuan Liu, Bei Du, Ruihua Wei, Hong Nian
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
m6A
macrophage polarization
miR‐31‐5p
p2x7 receptor
sjogren's syndrome dry eye
Online Access:https://doi.org/10.1002/advs.202415341
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