Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges

Abstract Background Value-adaptive designs for clinical trials are a novel set of emerging methods for delivering greater value for clinical research. There is increasing interest in using them within publicly funded health systems. A value-adaptive design permits ‘in progress’ changes to be made to...

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Bibliographic Details
Main Authors: Laura Flight, Alan Brennan, Stephen E. Chick, Martin Forster, Steven Julious, Puvan Tharmanathan
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-025-02566-6
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