Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy
The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/512695 |
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| author | Urszula Grzybowska-Chlebowczyk Halina Woś Aleksander L. Sieroń Sabina Więcek Aleksandra Auguściak-Duma Halina Koryciak-Komarska Joanna Kasznia-Kocot |
| author_facet | Urszula Grzybowska-Chlebowczyk Halina Woś Aleksander L. Sieroń Sabina Więcek Aleksandra Auguściak-Duma Halina Koryciak-Komarska Joanna Kasznia-Kocot |
| author_sort | Urszula Grzybowska-Chlebowczyk |
| collection | DOAJ |
| description | The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA.
Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15. |
| format | Article |
| id | doaj-art-046369d712dd4509a147ee9baee7711c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-046369d712dd4509a147ee9baee7711c2025-02-03T01:10:50ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/512695512695Serologic Investigations in Children with Inflammatory Bowel Disease and Food AllergyUrszula Grzybowska-Chlebowczyk0Halina Woś1Aleksander L. Sieroń2Sabina Więcek3Aleksandra Auguściak-Duma4Halina Koryciak-Komarska5Joanna Kasznia-Kocot6Gastroenterology Division, Department of Paediatrics, Medical University of Silesia, 40-752 Katowice, PolandGastroenterology Division, Department of Paediatrics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General, Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandGastroenterology Division, Department of Paediatrics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General, Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General, Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandGastroenterology Division, Department of Paediatrics, Medical University of Silesia, 40-752 Katowice, PolandThe aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15.http://dx.doi.org/10.1155/2009/512695 |
| spellingShingle | Urszula Grzybowska-Chlebowczyk Halina Woś Aleksander L. Sieroń Sabina Więcek Aleksandra Auguściak-Duma Halina Koryciak-Komarska Joanna Kasznia-Kocot Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy Mediators of Inflammation |
| title | Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy |
| title_full | Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy |
| title_fullStr | Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy |
| title_full_unstemmed | Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy |
| title_short | Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy |
| title_sort | serologic investigations in children with inflammatory bowel disease and food allergy |
| url | http://dx.doi.org/10.1155/2009/512695 |
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