Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70
Leukemia is a malignant tumor of the hematopoietic system. Approximately 15% of adult leukemias are chronic myeloid leukemias (CMLs), and this incidence increases annually. The BCR-ABL oncoprotein drives the initiation, promotion, and progression of CML. Although tyrosine kinase inhibitors (TKIs) ar...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/11/2294 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849330568273068032 |
|---|---|
| author | Miaomiao Zhang Jinfeng Wang Rongsong Jiang Ming Liu Weiyi Zhang |
| author_facet | Miaomiao Zhang Jinfeng Wang Rongsong Jiang Ming Liu Weiyi Zhang |
| author_sort | Miaomiao Zhang |
| collection | DOAJ |
| description | Leukemia is a malignant tumor of the hematopoietic system. Approximately 15% of adult leukemias are chronic myeloid leukemias (CMLs), and this incidence increases annually. The BCR-ABL oncoprotein drives the initiation, promotion, and progression of CML. Although tyrosine kinase inhibitors (TKIs) are first-line therapies for CML, BCR-ABL-mediated drug resistance limits their clinical efficacy and patient prognosis. Perillaldehyde (PAE), a monoterpene and primary volatile oil from perilla, is a promising small-molecule candidate for degrading BCR-ABL and has potential medical applications. The molecular mechanism showed that PAE regulated the expression of autophagy- and apoptosis-related proteins in K562 cells. Confocal laser observation showed that PAE damaged the mitochondrial membrane potential and induced ROS generation. Further evaluations indicated that PAE targeted HSP70 and inactivated the phosphorylation of BCR-ABL, thereby inhibiting its downstream proteins. This study may produce a lead compound for CML therapy as PAE may be an effective treatment for further exploration. |
| format | Article |
| id | doaj-art-04623c6607c042b2939089bc5f8da2d7 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-04623c6607c042b2939089bc5f8da2d72025-08-20T03:46:53ZengMDPI AGMolecules1420-30492025-05-013011229410.3390/molecules30112294Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70Miaomiao Zhang0Jinfeng Wang1Rongsong Jiang2Ming Liu3Weiyi Zhang4School of Pharmacy, Xinjiang Medical University, Urumchi 830017, ChinaSchool of Pharmacy, Xinjiang Medical University, Urumchi 830017, ChinaSchool of Pharmacy, Xinjiang Medical University, Urumchi 830017, ChinaSchool of Pharmacy, Xinjiang Medical University, Urumchi 830017, ChinaSchool of Pharmacy, Xinjiang Medical University, Urumchi 830017, ChinaLeukemia is a malignant tumor of the hematopoietic system. Approximately 15% of adult leukemias are chronic myeloid leukemias (CMLs), and this incidence increases annually. The BCR-ABL oncoprotein drives the initiation, promotion, and progression of CML. Although tyrosine kinase inhibitors (TKIs) are first-line therapies for CML, BCR-ABL-mediated drug resistance limits their clinical efficacy and patient prognosis. Perillaldehyde (PAE), a monoterpene and primary volatile oil from perilla, is a promising small-molecule candidate for degrading BCR-ABL and has potential medical applications. The molecular mechanism showed that PAE regulated the expression of autophagy- and apoptosis-related proteins in K562 cells. Confocal laser observation showed that PAE damaged the mitochondrial membrane potential and induced ROS generation. Further evaluations indicated that PAE targeted HSP70 and inactivated the phosphorylation of BCR-ABL, thereby inhibiting its downstream proteins. This study may produce a lead compound for CML therapy as PAE may be an effective treatment for further exploration.https://www.mdpi.com/1420-3049/30/11/2294perillaldehydechronic myeloid leukemiaapoptosisautophagyHSP70 |
| spellingShingle | Miaomiao Zhang Jinfeng Wang Rongsong Jiang Ming Liu Weiyi Zhang Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70 Molecules perillaldehyde chronic myeloid leukemia apoptosis autophagy HSP70 |
| title | Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70 |
| title_full | Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70 |
| title_fullStr | Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70 |
| title_full_unstemmed | Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70 |
| title_short | Unlocking the Potential of Perillaldehyde: A Novel Mechanism for Chronic Myeloid Leukemia by Targeting HSP70 |
| title_sort | unlocking the potential of perillaldehyde a novel mechanism for chronic myeloid leukemia by targeting hsp70 |
| topic | perillaldehyde chronic myeloid leukemia apoptosis autophagy HSP70 |
| url | https://www.mdpi.com/1420-3049/30/11/2294 |
| work_keys_str_mv | AT miaomiaozhang unlockingthepotentialofperillaldehydeanovelmechanismforchronicmyeloidleukemiabytargetinghsp70 AT jinfengwang unlockingthepotentialofperillaldehydeanovelmechanismforchronicmyeloidleukemiabytargetinghsp70 AT rongsongjiang unlockingthepotentialofperillaldehydeanovelmechanismforchronicmyeloidleukemiabytargetinghsp70 AT mingliu unlockingthepotentialofperillaldehydeanovelmechanismforchronicmyeloidleukemiabytargetinghsp70 AT weiyizhang unlockingthepotentialofperillaldehydeanovelmechanismforchronicmyeloidleukemiabytargetinghsp70 |