Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine
Introduction Magnesium is a crucial macroelement with widespread effects on the nervous and muscular systems.. Due to its role as an NMDA receptor antagonist, magnesium has garnered significant attention in pain management research, particularly for its potential to modulate both acute and chron...
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Kazimierz Wielki University
2025-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57571 |
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| author | Anna Konarska Artur Fabijański Adriana Dukacz Wojciech Firlej Joanna Rychlewska-Duda Justyna Lisiecka Michał Nowak Mateusz Janik Barbara Ufnalska Anna Machowiak |
| author_facet | Anna Konarska Artur Fabijański Adriana Dukacz Wojciech Firlej Joanna Rychlewska-Duda Justyna Lisiecka Michał Nowak Mateusz Janik Barbara Ufnalska Anna Machowiak |
| author_sort | Anna Konarska |
| collection | DOAJ |
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Introduction
Magnesium is a crucial macroelement with widespread effects on the nervous and muscular systems.. Due to its role as an NMDA receptor antagonist, magnesium has garnered significant attention in pain management research, particularly for its potential to modulate both acute and chronic pain. This article provides an overview of magnesium's therapeutic applications in neuropathic pain, migraine, and perioperative pain, drawing on research from PubMed and Google Scholar published between 1988 and 2025.
Aim of study
This review aims to present the state of knowledge about magnesium’s possible role in pain control and present mechanism of its influence on the nociceptive stimuli reception.
Materials and methods
Publication research was made using databases PubMed and Google Scholar. Keywords used in research were among others: magnesium, pain, neuropathic pain, migraine, perioperative pain, magnesium deficiency.
Current state of knowledge
Magnesium plays a crucial role in the management of various pain conditions, including perioperative, neuropathic, and migraine pain, through its multifactorial mechanisms. These include NMDA receptor antagonism, calcium channel blockade, anti-inflammatory effects, and muscle relaxation, all of which contribute to its analgesic properties. Evidence suggests that magnesium supplementation can reduce opioid use, counteract central and peripheral sensitization, and potentially prevent migraine attacks, highlighting its potential as an effective adjuvant in pain management strategies.
Summary (Conclusions):
Magnesium offers significant therapeutic potential in managing perioperative, neuropathic, and migraine pain through mechanisms such as NMDA receptor antagonism, calcium channel blockade, and neuroinflammation modulation. Its use can reduce opioid consumption, enhance pain relief, and improve outcomes, highlighting the need for further research into its clinical applications in pain management.
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| format | Article |
| id | doaj-art-04603295a9e74ced9f22e35e7dc31406 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-04603295a9e74ced9f22e35e7dc314062025-02-08T08:18:28ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-02-017810.12775/JEHS.2025.78.57571Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraineAnna Konarska0https://orcid.org/0009-0002-0142-6970Artur Fabijański1https://orcid.org/0000-0001-8639-6154Adriana Dukacz2https://orcid.org/0009-0007-4428-8789Wojciech Firlej3https://orcid.org/0009-0002-0813-2617Joanna Rychlewska-Duda4https://orcid.org/0009-0002-8992-1078Justyna Lisiecka5https://orcid.org/0009-0001-9545-910XMichał Nowak6https://orcid.org/0000-0002-0087-4387Mateusz Janik7https://orcid.org/0009-0001-4679-6935Barbara Ufnalska8https://orcid.org/0000-0001-6334-1812Anna Machowiak9https://orcid.org/0009-0007-3868-2480F.Raszeja's Municipal Hospital ul. Adama Mickiewicza 2, 60-834 Poznań, PolandSpecialist Mother and Child Healthcare Facility, ul. Wrzoska 1, 60-663 Poznań, PolandHelidor Swiecicki Clinical Hospital, ul. Przybyszewskiego 49, 60-355, Poznań, PolandPoznan University of Medical Sciences, ul. Fredry 10, 61-701 Poznań, PolandCRO-MED Medical and Physiotherapy Clinic, Osiedle Edwarda Raczyńskiego 2/23, 62-020 Swarzędz, PolandPromienista Primary Healthcare Center, ul.Promienista 89, 60-141, Poznań, PolandPoznan University of Medical Sciences, ul. Fredry 10, 61-701 Poznań, PolandHCP Medical Center, 28 czerwca 1956 r. 194, 66-446 Poznań, PolandSpecialist Mother and Child Healthcare Facility, ul. Wrzoska 1, 60-663 Poznań, PolandSpecialist Mother and Child Healthcare Facility, ul. Wrzoska 1, 60-663 Poznań, Poland Introduction Magnesium is a crucial macroelement with widespread effects on the nervous and muscular systems.. Due to its role as an NMDA receptor antagonist, magnesium has garnered significant attention in pain management research, particularly for its potential to modulate both acute and chronic pain. This article provides an overview of magnesium's therapeutic applications in neuropathic pain, migraine, and perioperative pain, drawing on research from PubMed and Google Scholar published between 1988 and 2025. Aim of study This review aims to present the state of knowledge about magnesium’s possible role in pain control and present mechanism of its influence on the nociceptive stimuli reception. Materials and methods Publication research was made using databases PubMed and Google Scholar. Keywords used in research were among others: magnesium, pain, neuropathic pain, migraine, perioperative pain, magnesium deficiency. Current state of knowledge Magnesium plays a crucial role in the management of various pain conditions, including perioperative, neuropathic, and migraine pain, through its multifactorial mechanisms. These include NMDA receptor antagonism, calcium channel blockade, anti-inflammatory effects, and muscle relaxation, all of which contribute to its analgesic properties. Evidence suggests that magnesium supplementation can reduce opioid use, counteract central and peripheral sensitization, and potentially prevent migraine attacks, highlighting its potential as an effective adjuvant in pain management strategies. Summary (Conclusions): Magnesium offers significant therapeutic potential in managing perioperative, neuropathic, and migraine pain through mechanisms such as NMDA receptor antagonism, calcium channel blockade, and neuroinflammation modulation. Its use can reduce opioid consumption, enhance pain relief, and improve outcomes, highlighting the need for further research into its clinical applications in pain management. https://apcz.umk.pl/JEHS/article/view/57571magnesiumpainNMDA receptorperioperative painneuropathic painmigraine |
| spellingShingle | Anna Konarska Artur Fabijański Adriana Dukacz Wojciech Firlej Joanna Rychlewska-Duda Justyna Lisiecka Michał Nowak Mateusz Janik Barbara Ufnalska Anna Machowiak Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine Journal of Education, Health and Sport magnesium pain NMDA receptor perioperative pain neuropathic pain migraine |
| title | Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine |
| title_full | Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine |
| title_fullStr | Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine |
| title_full_unstemmed | Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine |
| title_short | Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine |
| title_sort | magnesium in pain control mechanisms of action in perioperative pain neuropathic pain and migraine |
| topic | magnesium pain NMDA receptor perioperative pain neuropathic pain migraine |
| url | https://apcz.umk.pl/JEHS/article/view/57571 |
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