The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities
Postgenomic analysis of the effects of active ingredients of drugs involves the evaluation of the effects of relevant molecules on the transcription of genes (transcriptomes), on the changes in the activity of proteins (proteomes), and on the activity of molecular cascades (reactomes). The paper giv...
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| Language: | Russian |
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IMA-PRESS LLC
2018-12-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/874 |
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| author | I. Yu. Torshin O. A. Gromova A. M. Lila A. V. Naumov M. A. Sorokina K. V. Rudakov |
| author_facet | I. Yu. Torshin O. A. Gromova A. M. Lila A. V. Naumov M. A. Sorokina K. V. Rudakov |
| author_sort | I. Yu. Torshin |
| collection | DOAJ |
| description | Postgenomic analysis of the effects of active ingredients of drugs involves the evaluation of the effects of relevant molecules on the transcription of genes (transcriptomes), on the changes in the activity of proteins (proteomes), and on the activity of molecular cascades (reactomes). The paper gives the results of applying the current chemoinformational approaches to the postgenomic analysis of the effects of glucosamine sulfate (GS). The main result of the investigation is to simultaneously establish the synergistic effect of GS on transcriptomes, proteomes, and reactomes. In particular, GS assists in reducing not only the transcription of genes involved in the NF-κB proinflammatory signaling cascade (NFKB2, TNFRSF1B, PYCARD, TRAF2, TNFSF12, etc.), but also the activity of proteomic proteins that transmit a signal at different levels of the NF-κB cascade (CD44, TLR4, ICAM1, NF-κB, JAK/STAT, etc.). The complex anti-inflammatory effect of GS in reducing the synthesis of proinflammatory cytokines and weakening their effects on the cells is pathogenetic in the treatment of not only osteoarthritis, but also comorbidities accompanied by chronic inflammation. |
| format | Article |
| id | doaj-art-045a6f31bac74bbcb4eb4c0b04d315e0 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-045a6f31bac74bbcb4eb4c0b04d315e02025-08-20T03:01:22ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2018-12-0112412913610.14412/1996-7012-2018-4-129-1362138The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbiditiesI. Yu. Torshin0O. A. Gromova1A. M. Lila2A. V. Naumov3M. A. Sorokina4K. V. Rudakov5Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences.Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences.V.A. Nasonova Research Institute of Rheumatology.Russian Gerontology Research and Clinical Center.Dmitry Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology, and Immunology.Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences.Postgenomic analysis of the effects of active ingredients of drugs involves the evaluation of the effects of relevant molecules on the transcription of genes (transcriptomes), on the changes in the activity of proteins (proteomes), and on the activity of molecular cascades (reactomes). The paper gives the results of applying the current chemoinformational approaches to the postgenomic analysis of the effects of glucosamine sulfate (GS). The main result of the investigation is to simultaneously establish the synergistic effect of GS on transcriptomes, proteomes, and reactomes. In particular, GS assists in reducing not only the transcription of genes involved in the NF-κB proinflammatory signaling cascade (NFKB2, TNFRSF1B, PYCARD, TRAF2, TNFSF12, etc.), but also the activity of proteomic proteins that transmit a signal at different levels of the NF-κB cascade (CD44, TLR4, ICAM1, NF-κB, JAK/STAT, etc.). The complex anti-inflammatory effect of GS in reducing the synthesis of proinflammatory cytokines and weakening their effects on the cells is pathogenetic in the treatment of not only osteoarthritis, but also comorbidities accompanied by chronic inflammation.https://mrj.ima-press.net/mrj/article/view/874molecular pharmacological analysisglucosamine sulfatesustaguard® artroosteoarthritiscomorbidity |
| spellingShingle | I. Yu. Torshin O. A. Gromova A. M. Lila A. V. Naumov M. A. Sorokina K. V. Rudakov The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities Современная ревматология molecular pharmacological analysis glucosamine sulfate sustaguard® artro osteoarthritis comorbidity |
| title | The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities |
| title_full | The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities |
| title_fullStr | The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities |
| title_full_unstemmed | The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities |
| title_short | The results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities |
| title_sort | results of postgenomic analysis of a glucosamine sulfate molecule indicate the prospects of treatment for comorbidities |
| topic | molecular pharmacological analysis glucosamine sulfate sustaguard® artro osteoarthritis comorbidity |
| url | https://mrj.ima-press.net/mrj/article/view/874 |
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