tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer

tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer

BackgroundImmune escape remains a major challenge in cancer immunotherapy. Transfer RNA (tRNA)-derived small RNA (tsRNA) represents a novel class of non-coding RNAs generated from tRNA cleavage, regulating gene expression at transcriptional and translational levels. These tsRNAs exhibit diverse biol...

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Bibliographic Details
Main Authors: Jing Zhang, Chunlin Ou, Xin Li, Li Fu, Qizhi Luo, Jie Wang, Yizhou Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
tsRNA
3’ tRF-AlaCGC
MICA
ADAM10
NK cells
immune evasion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620550/full
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