Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis

Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis

Abstract Background Immune-related myocarditis induced by immune checkpoint inhibitors (ICIs) is a rare immune-related adverse event (irAE) but is characterized by a high mortality rate. However, the specific pathological mechanisms underlying immune-related myocarditis remain largely unclear. In th...

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Bibliographic Details
Main Authors: Boyu Sun, Ziyu Xun, Zixiang Zhou, Nan Zhang, Mingjian Piao, Chengjie Li, Jiongyuan Li, Shuofeng Li, Longhao Zhang, Xiangqi Chen, Hanping Wang, Haitao Zhao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Immune checkpoint inhibitor
Immune-related myocarditis
Single-cell RNA sequencing
Intercellular communication
Inflammatory microenvironment
Online Access:https://doi.org/10.1186/s12967-025-06551-x
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