Metabolic syndrome and dermatological diseases: association and treatment
Abstract Metabolic syndrome (MetS) is a clinical syndrome associated with cardiovascular disease, diabetes, obesity, and dyslipidemia. Its primary features include dyslipidemia, hypertension, abdominal obesity, and insulin resistance (IR). Recently, research has revealed that MetS is not only a mani...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Nutrition & Metabolism |
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| Online Access: | https://doi.org/10.1186/s12986-025-00924-1 |
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| author | Jiali Xia Li Ding Guoyan Liu |
| author_facet | Jiali Xia Li Ding Guoyan Liu |
| author_sort | Jiali Xia |
| collection | DOAJ |
| description | Abstract Metabolic syndrome (MetS) is a clinical syndrome associated with cardiovascular disease, diabetes, obesity, and dyslipidemia. Its primary features include dyslipidemia, hypertension, abdominal obesity, and insulin resistance (IR). Recently, research has revealed that MetS is not only a manifestation of internal metabolic disturbances but is also closely associated with various dermatological conditions, including inflammatory skin diseases, autoimmune skin diseases, and skin tumors. These studies have clarified the complex mechanisms underlying the interaction between MetS and these skin diseases, including IR, chronic inflammatory responses, and oxidative stress. This review summarizes the association between MetS and related dermatological conditions and their shared physiological mechanisms. It aims to provide clinicians with new therapeutic strategies and preventive measures to improve the treatment outcomes and quality of life of patients with skin conditions. |
| format | Article |
| id | doaj-art-04556bff59964afebab219923dca24a4 |
| institution | OA Journals |
| issn | 1743-7075 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj-art-04556bff59964afebab219923dca24a42025-08-20T01:49:39ZengBMCNutrition & Metabolism1743-70752025-05-0122112110.1186/s12986-025-00924-1Metabolic syndrome and dermatological diseases: association and treatmentJiali Xia0Li Ding1Guoyan Liu2Department of Dermatology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityDepartment of Dermatology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityHospital for Skin Diseases, Shandong First Medical UniversityAbstract Metabolic syndrome (MetS) is a clinical syndrome associated with cardiovascular disease, diabetes, obesity, and dyslipidemia. Its primary features include dyslipidemia, hypertension, abdominal obesity, and insulin resistance (IR). Recently, research has revealed that MetS is not only a manifestation of internal metabolic disturbances but is also closely associated with various dermatological conditions, including inflammatory skin diseases, autoimmune skin diseases, and skin tumors. These studies have clarified the complex mechanisms underlying the interaction between MetS and these skin diseases, including IR, chronic inflammatory responses, and oxidative stress. This review summarizes the association between MetS and related dermatological conditions and their shared physiological mechanisms. It aims to provide clinicians with new therapeutic strategies and preventive measures to improve the treatment outcomes and quality of life of patients with skin conditions.https://doi.org/10.1186/s12986-025-00924-1Metabolic syndromeDermatological diseasesInsulin resistanceChronic inflammationOxidative stressLipid metabolism |
| spellingShingle | Jiali Xia Li Ding Guoyan Liu Metabolic syndrome and dermatological diseases: association and treatment Nutrition & Metabolism Metabolic syndrome Dermatological diseases Insulin resistance Chronic inflammation Oxidative stress Lipid metabolism |
| title | Metabolic syndrome and dermatological diseases: association and treatment |
| title_full | Metabolic syndrome and dermatological diseases: association and treatment |
| title_fullStr | Metabolic syndrome and dermatological diseases: association and treatment |
| title_full_unstemmed | Metabolic syndrome and dermatological diseases: association and treatment |
| title_short | Metabolic syndrome and dermatological diseases: association and treatment |
| title_sort | metabolic syndrome and dermatological diseases association and treatment |
| topic | Metabolic syndrome Dermatological diseases Insulin resistance Chronic inflammation Oxidative stress Lipid metabolism |
| url | https://doi.org/10.1186/s12986-025-00924-1 |
| work_keys_str_mv | AT jialixia metabolicsyndromeanddermatologicaldiseasesassociationandtreatment AT liding metabolicsyndromeanddermatologicaldiseasesassociationandtreatment AT guoyanliu metabolicsyndromeanddermatologicaldiseasesassociationandtreatment |