Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity

Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity

BackgroundDoxorubicin (DOX) is a widely used chemotherapeutic agent known for its efficacy against various cancers, but its clinical application is often limited by its cardiotoxic effects. The exact mechanisms of DOX-induced cardiotoxicity remain unclear, requiring further investigation. Early diag...

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Bibliographic Details
Main Authors: Jingjing Ding, Xianzhen Feng, Zhongqing Xu, Hong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cardiotoxicity
anticancer
metabolomics
biomarker
doxorubicin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1543636/full
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