Oral delivery of GLP-1 peptide using recombinant Lactobacillus gasseri for the treatment of type 2 diabetes mellitus

Oral delivery of GLP-1 peptide using recombinant Lactobacillus gasseri for the treatment of type 2 diabetes mellitus

ABSTRACT Glucagon-like peptide-1 (GLP-1) is an effective therapeutic peptide for the treatment of type 2 diabetes mellitus (T2DM). Here, we constructed an effective probiotic-based oral GLP-1 delivery system by engineering the probiotic strain of Lactobacillus gasseri (LgsGPA) to secrete GLP-1 fusio...

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Bibliographic Details
Main Authors: Zhiqiang Ke, Qianqian Ma, Xiaonan Ye, Yan Jin, Yanlin Wang, Xinyuan Zhao, Zhengding Su
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
glucagon-like peptide-1
advanced microbiome delivery
protein transduction domain
serum albumin binding peptide
oral delivery
GLP-1 analog
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02828-24
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