Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats
Introduction: Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation in...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/096293503310001619708 |
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| author | Yatin M. Shivkar Vijay L. Kumar |
| author_facet | Yatin M. Shivkar Vijay L. Kumar |
| author_sort | Yatin M. Shivkar |
| collection | DOAJ |
| description | Introduction: Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in latex-induced inflammation. |
| format | Article |
| id | doaj-art-0448de2e9a474ee98d461bc40498d24a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0448de2e9a474ee98d461bc40498d24a2025-08-20T03:55:23ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112529930210.1080/096293503310001619708Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in ratsYatin M. Shivkar0Vijay L. Kumar1Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaDepartment of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, IndiaIntroduction: Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in latex-induced inflammation.http://dx.doi.org/10.1080/096293503310001619708Calotropis proceraCarrageenanHistamineInflammationAnti-inflammatory drugs. |
| spellingShingle | Yatin M. Shivkar Vijay L. Kumar Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats Mediators of Inflammation Calotropis procera Carrageenan Histamine Inflammation Anti-inflammatory drugs. |
| title | Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats |
| title_full | Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats |
| title_fullStr | Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats |
| title_full_unstemmed | Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats |
| title_short | Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats |
| title_sort | histamine mediates the pro inflammatory effect of latex of calotropis procera in rats |
| topic | Calotropis procera Carrageenan Histamine Inflammation Anti-inflammatory drugs. |
| url | http://dx.doi.org/10.1080/096293503310001619708 |
| work_keys_str_mv | AT yatinmshivkar histaminemediatestheproinflammatoryeffectoflatexofcalotropisprocerainrats AT vijaylkumar histaminemediatestheproinflammatoryeffectoflatexofcalotropisprocerainrats |