The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis
Aim. To estimate the clinical significance of anti-acetylcholine receptor antibody (anti-AChR-Ab) levels in suspected ocular myasthenia gravis. Methods. In total, 144 patients complaining of fluctuating diplopia and ptosis were evaluated for serum levels of anti-acetylcholine receptor antibody and t...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/689792 |
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| author | Jung Jin Lee Kyung Min Koh Ungsoo Samuel Kim |
| author_facet | Jung Jin Lee Kyung Min Koh Ungsoo Samuel Kim |
| author_sort | Jung Jin Lee |
| collection | DOAJ |
| description | Aim. To estimate the clinical significance of anti-acetylcholine receptor antibody (anti-AChR-Ab) levels in suspected ocular myasthenia gravis. Methods. In total, 144 patients complaining of fluctuating diplopia and ptosis were evaluated for serum levels of anti-acetylcholine receptor antibody and their medical charts were retrospectively reviewed. Subjects were classified into three groups: variable diplopia only, ptosis only, and both variable diplopia and ptosis. We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests. Results. Patients’ chief complaints were diplopia (N=103), ptosis (N=12), and their concurrence (N=29). Abnormal anti-AChR-Ab was observed in 21 of 144 patients (14.1%). Between the three groups, mean age, number of seropositive patients, and mean anti-AChR-Ab level were not significantly different (P=0.224, 0.073, and 0.062, resp.). Overall, 27.5% of patients had abnormal thyroid autoantibodies. Conclusion. The sensitivity of anti-AChR-Ab was 14.1% in suspected ocular myasthenia gravis and seropositivity in myasthenia gravis patients showed a high correlation with the presence of thyroid autoantibodies. |
| format | Article |
| id | doaj-art-044406e823f1469789ae5b6c868bf5a8 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-044406e823f1469789ae5b6c868bf5a82025-02-03T01:32:40ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/689792689792The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia GravisJung Jin Lee0Kyung Min Koh1Ungsoo Samuel Kim2Department of Ophthalmology, Kim’s Eye Hospital, Konyang University College of Medicine, Youngdeungpo 4th 156, Youngdeungpo-gu, Seoul 150-034, Republic of KoreaDepartment of Ophthalmology, Kim’s Eye Hospital, Konyang University College of Medicine, Youngdeungpo 4th 156, Youngdeungpo-gu, Seoul 150-034, Republic of KoreaDepartment of Ophthalmology, Kim’s Eye Hospital, Konyang University College of Medicine, Youngdeungpo 4th 156, Youngdeungpo-gu, Seoul 150-034, Republic of KoreaAim. To estimate the clinical significance of anti-acetylcholine receptor antibody (anti-AChR-Ab) levels in suspected ocular myasthenia gravis. Methods. In total, 144 patients complaining of fluctuating diplopia and ptosis were evaluated for serum levels of anti-acetylcholine receptor antibody and their medical charts were retrospectively reviewed. Subjects were classified into three groups: variable diplopia only, ptosis only, and both variable diplopia and ptosis. We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests. Results. Patients’ chief complaints were diplopia (N=103), ptosis (N=12), and their concurrence (N=29). Abnormal anti-AChR-Ab was observed in 21 of 144 patients (14.1%). Between the three groups, mean age, number of seropositive patients, and mean anti-AChR-Ab level were not significantly different (P=0.224, 0.073, and 0.062, resp.). Overall, 27.5% of patients had abnormal thyroid autoantibodies. Conclusion. The sensitivity of anti-AChR-Ab was 14.1% in suspected ocular myasthenia gravis and seropositivity in myasthenia gravis patients showed a high correlation with the presence of thyroid autoantibodies.http://dx.doi.org/10.1155/2014/689792 |
| spellingShingle | Jung Jin Lee Kyung Min Koh Ungsoo Samuel Kim The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis Journal of Ophthalmology |
| title | The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis |
| title_full | The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis |
| title_fullStr | The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis |
| title_full_unstemmed | The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis |
| title_short | The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis |
| title_sort | anti acetylcholine receptor antibody test in suspected ocular myasthenia gravis |
| url | http://dx.doi.org/10.1155/2014/689792 |
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