Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population
Abstract Schizophrenia (SZ) is a complex neuropsychiatric disorder influenced by genetic, environmental, and epigenetic factors, including miRNA dysregulation. This study explored the diagnostic and therapeutic potential of miRNAs in SZ, focusing on seven key miRNAs: miR-137-3p, miR-34a-5p, miR-432-...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-01831-4 |
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| author | Nabila M. Adly Dalia Khalifa Shaimaa Abdel-Ghany Hussein Sabit |
| author_facet | Nabila M. Adly Dalia Khalifa Shaimaa Abdel-Ghany Hussein Sabit |
| author_sort | Nabila M. Adly |
| collection | DOAJ |
| description | Abstract Schizophrenia (SZ) is a complex neuropsychiatric disorder influenced by genetic, environmental, and epigenetic factors, including miRNA dysregulation. This study explored the diagnostic and therapeutic potential of miRNAs in SZ, focusing on seven key miRNAs: miR-137-3p, miR-34a-5p, miR-432-5p, miR-130b-3p, miR-346, miR-195-5p, and miR-103a-3p. Results revealed significant dysregulation of miR-137-3p, miR-195-5p, miR-346, and miR-103a-3p, highlighting their relevance to SZ pathology. Upregulation of miR-137-3p correlated with enhanced cognitive performance, as evidenced by improved scores on the Wisconsin Card Sorting Test (WCST) and Trail Making Test B (TMT-B). Conversely, miR-195-5p and miR-346 were strongly associated with cognitive processing speed, while miR-103a-3p downregulation was linked to reduced conceptual flexibility. Cluster analyses demonstrated that miRNA expression levels varied significantly based on antipsychotic treatment and receptor targeting, suggesting potential regulatory effects of medication. Importantly, miRNAs were measured in PBMCs, highlighting their feasibility as non-invasive biomarkers. The study underscores the diagnostic value of miRNAs, offering a promising avenue for early detection and personalized interventions in SZ. Future research should validate these findings across diverse cohorts and investigate miRNA-based therapeutic strategies. By integrating miRNA profiling into clinical practice, this study provides a foundation for advancing precision medicine in SZ management. |
| format | Article |
| id | doaj-art-043e2b2083cd48cbbdc63d5e12d844d0 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-043e2b2083cd48cbbdc63d5e12d844d02025-08-20T02:32:07ZengNature PortfolioScientific Reports2045-23222025-05-0115112510.1038/s41598-025-01831-4Dysregulation of MiRNAs in schizophrenia in an Egyptian patient populationNabila M. Adly0Dalia Khalifa1Shaimaa Abdel-Ghany2Hussein Sabit3Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and TechnologyPsychiatry Department, Kasr Al Ainy Hospitals, Cairo UniversityDepartment of Environmental Biotechnology, College of Biotechnology, Misr University for Science and TechnologyDepartment of Medical Biotechnology, College of Biotechnology, Misr University for Science and TechnologyAbstract Schizophrenia (SZ) is a complex neuropsychiatric disorder influenced by genetic, environmental, and epigenetic factors, including miRNA dysregulation. This study explored the diagnostic and therapeutic potential of miRNAs in SZ, focusing on seven key miRNAs: miR-137-3p, miR-34a-5p, miR-432-5p, miR-130b-3p, miR-346, miR-195-5p, and miR-103a-3p. Results revealed significant dysregulation of miR-137-3p, miR-195-5p, miR-346, and miR-103a-3p, highlighting their relevance to SZ pathology. Upregulation of miR-137-3p correlated with enhanced cognitive performance, as evidenced by improved scores on the Wisconsin Card Sorting Test (WCST) and Trail Making Test B (TMT-B). Conversely, miR-195-5p and miR-346 were strongly associated with cognitive processing speed, while miR-103a-3p downregulation was linked to reduced conceptual flexibility. Cluster analyses demonstrated that miRNA expression levels varied significantly based on antipsychotic treatment and receptor targeting, suggesting potential regulatory effects of medication. Importantly, miRNAs were measured in PBMCs, highlighting their feasibility as non-invasive biomarkers. The study underscores the diagnostic value of miRNAs, offering a promising avenue for early detection and personalized interventions in SZ. Future research should validate these findings across diverse cohorts and investigate miRNA-based therapeutic strategies. By integrating miRNA profiling into clinical practice, this study provides a foundation for advancing precision medicine in SZ management.https://doi.org/10.1038/s41598-025-01831-4SchizophreniaMiRNA dysregulationCognitive functionBiomarkersPersonalized medicine |
| spellingShingle | Nabila M. Adly Dalia Khalifa Shaimaa Abdel-Ghany Hussein Sabit Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population Scientific Reports Schizophrenia MiRNA dysregulation Cognitive function Biomarkers Personalized medicine |
| title | Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population |
| title_full | Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population |
| title_fullStr | Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population |
| title_full_unstemmed | Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population |
| title_short | Dysregulation of MiRNAs in schizophrenia in an Egyptian patient population |
| title_sort | dysregulation of mirnas in schizophrenia in an egyptian patient population |
| topic | Schizophrenia MiRNA dysregulation Cognitive function Biomarkers Personalized medicine |
| url | https://doi.org/10.1038/s41598-025-01831-4 |
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