Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway
Slow transit constipation (STC) is a type of functional constipation resulting from a lack of intestinal motility. The primary symptoms are challenging defecation and desiccated feces, which may readily result in perianal, cardiovascular, cerebrovascular, and psychological disorders. The structural...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1598806/full |
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| author | Zu Gao Liwen Fu Wenjun Bai Junwei Liang |
| author_facet | Zu Gao Liwen Fu Wenjun Bai Junwei Liang |
| author_sort | Zu Gao |
| collection | DOAJ |
| description | Slow transit constipation (STC) is a type of functional constipation resulting from a lack of intestinal motility. The primary symptoms are challenging defecation and desiccated feces, which may readily result in perianal, cardiovascular, cerebrovascular, and psychological disorders. The structural and morphological impairment of the enteric nervous system (ENS), along with the dysfunction of interstitial cells of Cajal (ICCs) and smooth muscle cells (SMCs), are the primary contributors to the onset and progression of STC. In recent years, traditional Chinese medicine (TCM) has emerged as an alternative for the therapeutic prevention and treatment of STC. Metabolites obtained from botanical drugs, including quercetin and nobiletin, may ameliorate symptoms of STC, presenting a possible therapeutic approach for STC. This review summarizes metabolites derived from botanical drugs, including flavonoids, terpenoids, steroids, polysaccharides, anthraquinones, and phenylpropanoids, emphasizing their regulatory mechanisms in the treatment of STC via the ENS-ICC-SMC pathway, while also addressing future challenges and developmental directions. |
| format | Article |
| id | doaj-art-043d09e7c9014cee89f743bf417b8181 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-043d09e7c9014cee89f743bf417b81812025-08-20T03:10:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15988061598806Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathwayZu Gao0Liwen Fu1Wenjun Bai2Junwei Liang3College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaSlow transit constipation (STC) is a type of functional constipation resulting from a lack of intestinal motility. The primary symptoms are challenging defecation and desiccated feces, which may readily result in perianal, cardiovascular, cerebrovascular, and psychological disorders. The structural and morphological impairment of the enteric nervous system (ENS), along with the dysfunction of interstitial cells of Cajal (ICCs) and smooth muscle cells (SMCs), are the primary contributors to the onset and progression of STC. In recent years, traditional Chinese medicine (TCM) has emerged as an alternative for the therapeutic prevention and treatment of STC. Metabolites obtained from botanical drugs, including quercetin and nobiletin, may ameliorate symptoms of STC, presenting a possible therapeutic approach for STC. This review summarizes metabolites derived from botanical drugs, including flavonoids, terpenoids, steroids, polysaccharides, anthraquinones, and phenylpropanoids, emphasizing their regulatory mechanisms in the treatment of STC via the ENS-ICC-SMC pathway, while also addressing future challenges and developmental directions.https://www.frontiersin.org/articles/10.3389/fphar.2025.1598806/fullslow transit constipationmetabolites from botanical drugstraditional Chinese medicinepharmacological effectsENS-ICC-SMC pathway |
| spellingShingle | Zu Gao Liwen Fu Wenjun Bai Junwei Liang Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway Frontiers in Pharmacology slow transit constipation metabolites from botanical drugs traditional Chinese medicine pharmacological effects ENS-ICC-SMC pathway |
| title | Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway |
| title_full | Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway |
| title_fullStr | Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway |
| title_full_unstemmed | Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway |
| title_short | Protective effects of medicinal plant-derived metabolites on slow transit constipation via the ENS-ICC-SMC pathway |
| title_sort | protective effects of medicinal plant derived metabolites on slow transit constipation via the ens icc smc pathway |
| topic | slow transit constipation metabolites from botanical drugs traditional Chinese medicine pharmacological effects ENS-ICC-SMC pathway |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1598806/full |
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