Unlocking Testosterone Production by Biotransformation: Engineering a Fungal Model of <i>Aspergillus nidulans</i> Strain Deficient in Steroid 11α-Hydroxylase Activity and Expressing 17β-Hydroxysteroid Dehydrogenase Enzyme as Proof of Concept

Unlocking Testosterone Production by Biotransformation: Engineering a Fungal Model of <i>Aspergillus nidulans</i> Strain Deficient in Steroid 11α-Hydroxylase Activity and Expressing 17β-Hydroxysteroid Dehydrogenase Enzyme as Proof of Concept

Testosterone holds significant medical and economic importance, with the global market for testosterone replacement therapies valued at approximately USD 1.9 billion in 2023. This hormone is essential for the development and maintenance of male sexual characteristics as well as bone and muscle healt...

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Bibliographic Details
Main Authors: Lidia Ortega-de los Ríos, Luis Getino, Beatriz Galán, José Luis García, José M. Luengo, Alejandro Chamizo-Ampudia, José M. Fernández-Cañón
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
<i>Aspergillus nidulans</i>
steroid 11α-hydroxylase
<i>Aspergillus ochraceus</i>
testosterone
17β-hydroxysteroid dehydrogenase (17β-HSD) EC 1.1.1.51
androstenedione
Online Access:https://www.mdpi.com/2218-273X/14/12/1502
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