Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes
We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amin...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/BCA/2006/59509 |
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| Summary: | We have synthesized a novel series of Schiff bases by condensation
of 4-aminoantipyrine and various aromatic aldehydes followed by
reaction with thiosemicarbazide. These thiosemicarbazones are
potential ligands toward transition metal ions. The reaction of
copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS),
4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone
(MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino]
antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene)
amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the
formation of solid complexes with the general composition
CuX2⋅(H2O)(L)(X = Cl, Br, NO3, NCS, or CH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized
through elemental analysis, molecular weight, electrical
conductance, infrared, electronic spectra, and magnetic
susceptibilities at room temperature. Copper(II) complexes with
BAAPTS and MBAAPTS were screened for antibacterial and antifungal
properties and have exhibited potential activity. Thermal
stabilities of two representative complexes were also investigated. |
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| ISSN: | 1565-3633 1687-479X |