Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome
Objective:To investigate the relationship between obstructive sleep apnoea (OSA) severity and oxygen desaturation with biomarkers including ischaemia-modified albumin (IMA), interleukin-1β (IL-1β), thiol/ disulphide homeostasis parameters, and cardiac biomarkers (BNP, NT-proBNP). Material and Method...
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| Format: | Article |
| Language: | English |
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Istanbul University Press
2025-03-01
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| Series: | The Turkish Journal of Ear Nose and Throat |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/EEA04A2990194799A54715A826E95538 |
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| author | Hamza Ogun Eray Metin Güler Beyza Nur Özkan Muhammed Yunus Bektay Abdullah Kansu Ömer Faruk Çalım |
| author_facet | Hamza Ogun Eray Metin Güler Beyza Nur Özkan Muhammed Yunus Bektay Abdullah Kansu Ömer Faruk Çalım |
| author_sort | Hamza Ogun |
| collection | DOAJ |
| description | Objective:To investigate the relationship between obstructive sleep apnoea (OSA) severity and oxygen desaturation with biomarkers including ischaemia-modified albumin (IMA), interleukin-1β (IL-1β), thiol/ disulphide homeostasis parameters, and cardiac biomarkers (BNP, NT-proBNP). Material and Methods:This cross-sectional study included 88 patients who underwent polysomnography at the Bezmialem Vakif University Sleep Laboratory. Participants were categorised into normal/mild OSA (n=36) and moderate/severe OSA (n=52) groups based on the apnoea-hypopnoea index (AHI). Blood samples were analysed for BNP, NT-proBNP, IMA, IL-1β, and thiol/disulphide homeostasis parameters. Results:The moderate/severe OSA group showed significantly higher levels of IMA (0.94±0.04 vs 0.88±0.04, p<0.001), IL-1β (359.82±121.14 vs 231.45±83.76 pg/mL, p<0.001), and lower levels of native thiol (345.23±69.85 vs 395.62±58.71 µmol/L, p<0.001) compared to the normal/mild group. BNP and NT-proBNP levels were moderately elevated in the moderate/severe OSA group (p=0.012 and p=0.003, respectively). Conclusion: IMA, IL-1β, and native thiol demonstrate promise as potential biomarkers for OSA severity. These findings confirm that oxidative stress and inflammation play significant roles in the pathophysi ology of OSA and offer new opportunities for diagnosis and monitoring. |
| format | Article |
| id | doaj-art-0433af2e50e84317beee9f96e31af8af |
| institution | Kabale University |
| issn | 2602-4837 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | The Turkish Journal of Ear Nose and Throat |
| spelling | doaj-art-0433af2e50e84317beee9f96e31af8af2025-08-20T03:48:52ZengIstanbul University PressThe Turkish Journal of Ear Nose and Throat2602-48372025-03-01351354010.26650/Tr-ENT.2025.1600469123456Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea SyndromeHamza Ogun0https://orcid.org/0000-0002-4799-9670Eray Metin Güler1https://orcid.org/0000-0003-4351-1719Beyza Nur Özkan2https://orcid.org/0000-0001-9707-9111Muhammed Yunus Bektay3https://orcid.org/0000-0003-2032-9957Abdullah Kansu4https://orcid.org/0000-0001-8902-5498Ömer Faruk Çalım5https://orcid.org/0000-0002-0010-9028Bezmiâlem Vakıf Üniversitesi, Istanbul, TurkiyeSağlık Bilimleri Üniversitesi, Istanbul, TurkiyeSağlık Bilimleri Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Medipol Üniversitesi, Istanbul, Turkiyeİstanbul Medipol Üniversitesi, Istanbul, TurkiyeObjective:To investigate the relationship between obstructive sleep apnoea (OSA) severity and oxygen desaturation with biomarkers including ischaemia-modified albumin (IMA), interleukin-1β (IL-1β), thiol/ disulphide homeostasis parameters, and cardiac biomarkers (BNP, NT-proBNP). Material and Methods:This cross-sectional study included 88 patients who underwent polysomnography at the Bezmialem Vakif University Sleep Laboratory. Participants were categorised into normal/mild OSA (n=36) and moderate/severe OSA (n=52) groups based on the apnoea-hypopnoea index (AHI). Blood samples were analysed for BNP, NT-proBNP, IMA, IL-1β, and thiol/disulphide homeostasis parameters. Results:The moderate/severe OSA group showed significantly higher levels of IMA (0.94±0.04 vs 0.88±0.04, p<0.001), IL-1β (359.82±121.14 vs 231.45±83.76 pg/mL, p<0.001), and lower levels of native thiol (345.23±69.85 vs 395.62±58.71 µmol/L, p<0.001) compared to the normal/mild group. BNP and NT-proBNP levels were moderately elevated in the moderate/severe OSA group (p=0.012 and p=0.003, respectively). Conclusion: IMA, IL-1β, and native thiol demonstrate promise as potential biomarkers for OSA severity. These findings confirm that oxidative stress and inflammation play significant roles in the pathophysi ology of OSA and offer new opportunities for diagnosis and monitoring.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/EEA04A2990194799A54715A826E95538obstructive sleep apnoeabiomarkersischaemia-modified albuminoxidative stressi̇nflammation |
| spellingShingle | Hamza Ogun Eray Metin Güler Beyza Nur Özkan Muhammed Yunus Bektay Abdullah Kansu Ömer Faruk Çalım Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome The Turkish Journal of Ear Nose and Throat obstructive sleep apnoea biomarkers ischaemia-modified albumin oxidative stress i̇nflammation |
| title | Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome |
| title_full | Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome |
| title_fullStr | Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome |
| title_full_unstemmed | Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome |
| title_short | Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome |
| title_sort | predictive value of natriuretic peptide tests and ischemia modified albumin levels in the diagnosis of obstructive sleep apnoea syndrome |
| topic | obstructive sleep apnoea biomarkers ischaemia-modified albumin oxidative stress i̇nflammation |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/EEA04A2990194799A54715A826E95538 |
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