Dual antibiotic PLGA microspheres for the treatment of traumatic osteomyelitis

Dual antibiotic PLGA microspheres for the treatment of traumatic osteomyelitis

Abstract Traumatic osteomyelitis (TO) treatment remains challenging due to biofilm formation and poor antibiotic penetration. We developed poly(lactic-co-glycolic acid) (PLGA) microspheres co-loaded with moxifloxacin/rifampicin (M/R-P) to address these limitations. Key findings: In vitro: The micros...

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Bibliographic Details
Main Authors: Liangguo Si, Wenping Zhang, Haifeng Jiang, Haiqiang Ma, Xu Ma, Peijie Zhao, Huanhuan Sun, Zhipeng Yang, Zewen Qiao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
PLGA, Moxifloxacin, Rifampicin, Osteomyelitis, Localized drug delivery, MRSA
Online Access:https://doi.org/10.1038/s41598-025-14824-0
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