Multiple signaling pathways in the frontiers of lung cancer progression
Lung cancer is a prevalent malignant tumor and the leading cause of cancer-related mortality worldwide. LC is a complex respiratory condition that poses significant challenges for both clinicians and researchers. Crucially, dysregulation of molecular signaling pathways is a key message point in LC....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593793/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850214248510128128 |
|---|---|
| author | Hao Liu Dujuan Zhou Yangjing Ou Shuanghua Chen Yunzhu Long Ting Yuan Yukun Li Yingzheng Tan Yingzheng Tan |
| author_facet | Hao Liu Dujuan Zhou Yangjing Ou Shuanghua Chen Yunzhu Long Ting Yuan Yukun Li Yingzheng Tan Yingzheng Tan |
| author_sort | Hao Liu |
| collection | DOAJ |
| description | Lung cancer is a prevalent malignant tumor and the leading cause of cancer-related mortality worldwide. LC is a complex respiratory condition that poses significant challenges for both clinicians and researchers. Crucially, dysregulation of molecular signaling pathways is a key message point in LC. Numerous reviews have highlighted effective treatments for LC by targeting disrupted signaling pathways. Understanding the roles and interconnections of various signaling pathways in LC is crucial. Therefore, this paper reviews the pathogenesis, biological functions and their important interactions in lung cancer. Frist, we reviewed relevant signaling pathways involved in LC, including Wnt, PI3K/Akt, Notch, PD-1/PD-L1, NF-κB, Hippo, MAPK, Hedgehog, AMPK. Immediately thereafter, we further explored the biological functions of LC in this area of pathophysiology, such as apoptosis, metastasis and proliferation. In conclusion, after our deeper understanding of the interactions of these signaling pathways in LC. And we must recognize that the interactions between the above signaling pathways can lead to comprehensive as well as novel therapeutic approaches for LC. |
| format | Article |
| id | doaj-art-04291e792cf8472cb9abca5165b0aa45 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-04291e792cf8472cb9abca5165b0aa452025-08-20T02:08:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15937931593793Multiple signaling pathways in the frontiers of lung cancer progressionHao Liu0Dujuan Zhou1Yangjing Ou2Shuanghua Chen3Yunzhu Long4Ting Yuan5Yukun Li6Yingzheng Tan7Yingzheng Tan8Zhuzhou Clinical College, Jishou University, Zhuzhou, Hunan, ChinaDepartment of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, ChinaDepartment of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, ChinaHunan Traditional Chinese Medicine College, Zhuzhou, Hunan, ChinaDepartment of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, ChinaDepartment of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, ChinaDepartment of Assisted Reproductive Centre, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, ChinaZhuzhou Clinical College, Jishou University, Zhuzhou, Hunan, ChinaDepartment of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, ChinaLung cancer is a prevalent malignant tumor and the leading cause of cancer-related mortality worldwide. LC is a complex respiratory condition that poses significant challenges for both clinicians and researchers. Crucially, dysregulation of molecular signaling pathways is a key message point in LC. Numerous reviews have highlighted effective treatments for LC by targeting disrupted signaling pathways. Understanding the roles and interconnections of various signaling pathways in LC is crucial. Therefore, this paper reviews the pathogenesis, biological functions and their important interactions in lung cancer. Frist, we reviewed relevant signaling pathways involved in LC, including Wnt, PI3K/Akt, Notch, PD-1/PD-L1, NF-κB, Hippo, MAPK, Hedgehog, AMPK. Immediately thereafter, we further explored the biological functions of LC in this area of pathophysiology, such as apoptosis, metastasis and proliferation. In conclusion, after our deeper understanding of the interactions of these signaling pathways in LC. And we must recognize that the interactions between the above signaling pathways can lead to comprehensive as well as novel therapeutic approaches for LC.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593793/fullsignal transductionlung cancertherapeutic targetsoncogenemetastasis |
| spellingShingle | Hao Liu Dujuan Zhou Yangjing Ou Shuanghua Chen Yunzhu Long Ting Yuan Yukun Li Yingzheng Tan Yingzheng Tan Multiple signaling pathways in the frontiers of lung cancer progression Frontiers in Immunology signal transduction lung cancer therapeutic targets oncogene metastasis |
| title | Multiple signaling pathways in the frontiers of lung cancer progression |
| title_full | Multiple signaling pathways in the frontiers of lung cancer progression |
| title_fullStr | Multiple signaling pathways in the frontiers of lung cancer progression |
| title_full_unstemmed | Multiple signaling pathways in the frontiers of lung cancer progression |
| title_short | Multiple signaling pathways in the frontiers of lung cancer progression |
| title_sort | multiple signaling pathways in the frontiers of lung cancer progression |
| topic | signal transduction lung cancer therapeutic targets oncogene metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593793/full |
| work_keys_str_mv | AT haoliu multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT dujuanzhou multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT yangjingou multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT shuanghuachen multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT yunzhulong multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT tingyuan multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT yukunli multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT yingzhengtan multiplesignalingpathwaysinthefrontiersoflungcancerprogression AT yingzhengtan multiplesignalingpathwaysinthefrontiersoflungcancerprogression |