Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species
The filamentous fungal genus Fusarium contains many species that cause catastrophic diseases in fruits, cereal, and vegetables. These diseases cause substantial losses in yield and contaminate affected crops with toxins. This causes huge losses in the agricultural sector and threatens human and anim...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1536532/full |
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| author | Alexander Dumbai Joe Runze Liu Xiao Luo Ruqiya Syed Farhan Aslam Zhenying Luo Zhitian Zheng |
| author_facet | Alexander Dumbai Joe Runze Liu Xiao Luo Ruqiya Syed Farhan Aslam Zhenying Luo Zhitian Zheng |
| author_sort | Alexander Dumbai Joe |
| collection | DOAJ |
| description | The filamentous fungal genus Fusarium contains many species that cause catastrophic diseases in fruits, cereal, and vegetables. These diseases cause substantial losses in yield and contaminate affected crops with toxins. This causes huge losses in the agricultural sector and threatens human and animal health. The most efficient approach to control the Fusarium spp. is fungicide application. Phenamacril is a site-specific fungicide that exerts its antifungal effect on sensitive Fusarium spp. It is a new fungicide developed that targets Fusarium graminearum by inhibiting myosin-5, an important protein in fungal growth and disease development. Because of its remarkable specificity, the new fungicide phenamacril is regarded as environmentally benign. However, many research findings have reported the emergence of the resistance of Fusarium spp. to phenamacril in both the field and laboratory. This article comprehensively analyzes the mechanisms underlying Fusarium spp. resistance to phenamacril. We examine the molecular, genetic, and environmental factors contributing to this resistance. We emphasize the importance of continued research and integrating different approaches to monitoring and managing drug-resistant Fusarium spp. populations. Integrating current inventions to inform strategies for sustainable disease control practices, and increase plant health, and yield will contribute to ongoing global efforts to achieve food and nutritional sustainability for the world's rapidly growing population while ensuring the effectiveness of the fungicidal product. |
| format | Article |
| id | doaj-art-04270f4800e942d0ad9edc9f0236c1c1 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-04270f4800e942d0ad9edc9f0236c1c12025-02-11T07:00:09ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.15365321536532Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium speciesAlexander Dumbai Joe0Runze Liu1Xiao Luo2Ruqiya Syed3Farhan Aslam4Zhenying Luo5Zhitian Zheng6School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an, ChinaSchool of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an, ChinaSchool of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an, ChinaSchool of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an, ChinaSchool of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an, ChinaGanzhou Vegetable and Flower Research Institute, Ganzhou, ChinaSchool of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an, ChinaThe filamentous fungal genus Fusarium contains many species that cause catastrophic diseases in fruits, cereal, and vegetables. These diseases cause substantial losses in yield and contaminate affected crops with toxins. This causes huge losses in the agricultural sector and threatens human and animal health. The most efficient approach to control the Fusarium spp. is fungicide application. Phenamacril is a site-specific fungicide that exerts its antifungal effect on sensitive Fusarium spp. It is a new fungicide developed that targets Fusarium graminearum by inhibiting myosin-5, an important protein in fungal growth and disease development. Because of its remarkable specificity, the new fungicide phenamacril is regarded as environmentally benign. However, many research findings have reported the emergence of the resistance of Fusarium spp. to phenamacril in both the field and laboratory. This article comprehensively analyzes the mechanisms underlying Fusarium spp. resistance to phenamacril. We examine the molecular, genetic, and environmental factors contributing to this resistance. We emphasize the importance of continued research and integrating different approaches to monitoring and managing drug-resistant Fusarium spp. populations. Integrating current inventions to inform strategies for sustainable disease control practices, and increase plant health, and yield will contribute to ongoing global efforts to achieve food and nutritional sustainability for the world's rapidly growing population while ensuring the effectiveness of the fungicidal product.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1536532/fullphenamacrilFusarium speciesmolecular mechanismsmyosins-5resistance |
| spellingShingle | Alexander Dumbai Joe Runze Liu Xiao Luo Ruqiya Syed Farhan Aslam Zhenying Luo Zhitian Zheng Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species Frontiers in Cellular and Infection Microbiology phenamacril Fusarium species molecular mechanisms myosins-5 resistance |
| title | Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species |
| title_full | Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species |
| title_fullStr | Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species |
| title_full_unstemmed | Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species |
| title_short | Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species |
| title_sort | comprehensive analysis of the mechanisms conferring resistance to phenamacril in the fusarium species |
| topic | phenamacril Fusarium species molecular mechanisms myosins-5 resistance |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1536532/full |
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