Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

It is well known that dendritic cells (DCs) play a pivotal role in triggering self-specific responses. Conversely, tolerogenic DCs (tolDCs), a specialized subset, induce tolerance and negatively regulate autoreactive responses. Tofacitinib, a Janus kinase inhibitor developed by Pfizer for treatment...

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Bibliographic Details
Main Authors:	Yan Zhou, Xiao Leng, Shasha Luo, Zhiwei Su, Xingyan Luo, Huijie Guo, Chunfen Mo, Qiang Zou, Yang Liu, Yantang Wang
Format:	Article
Language:	English
Published:	Wiley 2016-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2016/5021537
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