Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes
Gastrointestinal function plays a pivotal role in nutrient absorption and overall digestive health. Abnormal gastric emptying is closely linked to type 2 diabetes, impacting blood glucose regulation and causing gastrointestinal symptoms. This study aims to investigate and compare segmental transit t...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Circumpolar Health |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22423982.2024.2392406 |
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| author | Mads Mose Jensen Nadja Albertsen Anne-Marie Wegeberg Michael Lynge Pedersen Stig Andersen Christina Brock |
| author_facet | Mads Mose Jensen Nadja Albertsen Anne-Marie Wegeberg Michael Lynge Pedersen Stig Andersen Christina Brock |
| author_sort | Mads Mose Jensen |
| collection | DOAJ |
| description | Gastrointestinal function plays a pivotal role in nutrient absorption and overall digestive health. Abnormal gastric emptying is closely linked to type 2 diabetes, impacting blood glucose regulation and causing gastrointestinal symptoms. This study aims to investigate and compare segmental transit times, motility indices, and micromilieu between Greenlandic Inuit and Danish individuals with and without type 2 diabetes. We included forty-four Greenlandic Inuit, twenty-three of whom had type 2 diabetes, and age and gender-matched Danish individuals. Segmental transit time, motility, and luminal environment were measured using the SmartPill®. Greenlandic controls displayed shorter gastric emptying time (GET) (163 min), higher gastric median pH (2.0 pH) and duodenal median contractions (18.2 mm Hg) compared to Greenlanders with type 2 diabetes (GET: 235 min, pH:1.9, median duodenal contraction 18.4 mm Hg) and Danish controls (GET: 190, pH:1.2 median duodenal contraction 17.5 mmHg). Despite similar anti-diabetic management efforts, variations in gastrointestinal physiology were evident, highlighting the complexity of diabetes and its interaction with ethnicity, suggesting potential dietary or even genetic influences, emphasising the necessity for personalised diabetes management approaches. Finally, the study opens possibilities for future research, encouraging investigations into the underlying mechanisms linking genetics, diet, and gastric physiology, as an understanding of factors can lead to more effective, tailored strategies for diabetes care and improved digestive health in diverse populations. |
| format | Article |
| id | doaj-art-0419df3d794b43df8232c0904f30429d |
| institution | DOAJ |
| issn | 2242-3982 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Circumpolar Health |
| spelling | doaj-art-0419df3d794b43df8232c0904f30429d2025-08-20T02:49:06ZengTaylor & Francis GroupInternational Journal of Circumpolar Health2242-39822024-12-0183110.1080/22423982.2024.2392406Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetesMads Mose Jensen0Nadja Albertsen1Anne-Marie Wegeberg2Michael Lynge Pedersen3Stig Andersen4Christina Brock5Steno Diabetes Center Greenland, Queen Ingrid’s Hospital, Nuuk, GreenlandGreenland Center for Health Research, Institute of Health and Nature, University of Greenland, Nuuk, GreenlandDepartment of Clinical Medicine, Aalborg University, Aalborg, DenmarkSteno Diabetes Center Greenland, Queen Ingrid’s Hospital, Nuuk, GreenlandGreenland Center for Health Research, Institute of Health and Nature, University of Greenland, Nuuk, GreenlandDepartment of Clinical Medicine, Aalborg University, Aalborg, DenmarkGastrointestinal function plays a pivotal role in nutrient absorption and overall digestive health. Abnormal gastric emptying is closely linked to type 2 diabetes, impacting blood glucose regulation and causing gastrointestinal symptoms. This study aims to investigate and compare segmental transit times, motility indices, and micromilieu between Greenlandic Inuit and Danish individuals with and without type 2 diabetes. We included forty-four Greenlandic Inuit, twenty-three of whom had type 2 diabetes, and age and gender-matched Danish individuals. Segmental transit time, motility, and luminal environment were measured using the SmartPill®. Greenlandic controls displayed shorter gastric emptying time (GET) (163 min), higher gastric median pH (2.0 pH) and duodenal median contractions (18.2 mm Hg) compared to Greenlanders with type 2 diabetes (GET: 235 min, pH:1.9, median duodenal contraction 18.4 mm Hg) and Danish controls (GET: 190, pH:1.2 median duodenal contraction 17.5 mmHg). Despite similar anti-diabetic management efforts, variations in gastrointestinal physiology were evident, highlighting the complexity of diabetes and its interaction with ethnicity, suggesting potential dietary or even genetic influences, emphasising the necessity for personalised diabetes management approaches. Finally, the study opens possibilities for future research, encouraging investigations into the underlying mechanisms linking genetics, diet, and gastric physiology, as an understanding of factors can lead to more effective, tailored strategies for diabetes care and improved digestive health in diverse populations.https://www.tandfonline.com/doi/10.1080/22423982.2024.2392406Gastric emptyingtype 2 diabetesInuitGreenlandGastrointestinal function |
| spellingShingle | Mads Mose Jensen Nadja Albertsen Anne-Marie Wegeberg Michael Lynge Pedersen Stig Andersen Christina Brock Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes International Journal of Circumpolar Health Gastric emptying type 2 diabetes Inuit Greenland Gastrointestinal function |
| title | Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes |
| title_full | Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes |
| title_fullStr | Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes |
| title_full_unstemmed | Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes |
| title_short | Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes |
| title_sort | inuit population have shorter gastric emptying higher duodenal motility and altered pan enteric micromilieu a comparative study between greenlandic and danish populations with and without type 2 diabetes |
| topic | Gastric emptying type 2 diabetes Inuit Greenland Gastrointestinal function |
| url | https://www.tandfonline.com/doi/10.1080/22423982.2024.2392406 |
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