Antiproliferative and pro-apoptotic effects of Pseudevernia furfuracea (L.) Zopf extract and its active component physodic acid via oxidative stress and DNA damage in breast cancer cells

Antiproliferative and pro-apoptotic effects of Pseudevernia furfuracea (L.) Zopf extract and its active component physodic acid via oxidative stress and DNA damage in breast cancer cells

BackgroundMammary gland malignancies are the most diagnosed oncological diseases in women. The currently available treatment faces several problems, including resistance to cytostatics and the relatively high recurrence rates. These limitations have led to an increasing interest in natural substance...

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Main Authors: Dominika Sebova, Simona Zilakova, Viktoria Medvecova, Michal Goga, Richard Frenak, Annamaria Bardelcikova, Andrej Mirossay, Ladislav Mirossay, Jan Mojzis, Martin Kello
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
Pseudevernia furfuracea
physodic acid
breast cancer
apoptosis
oxidative damage
immune checkpoints
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1557884/full
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