Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study
Background: Acne is a chronic inflammatory skin disease. Photodynamic therapy (PDT) is a highly effective and safe drug-device combination treatment, typically using red and blue light. However, direct comparisons of aminolevulinic acid (ALA)-based PDT using these two light sources are lacking. Ther...
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Elsevier
2024-10-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024003624 |
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| author | Hengtong Fan Huihui Tuo Yuhan Xie Manyu Ju Yan Sun Yajie Yang Xinnan Han Zejun Ren Yan Zheng Dalin He |
| author_facet | Hengtong Fan Huihui Tuo Yuhan Xie Manyu Ju Yan Sun Yajie Yang Xinnan Han Zejun Ren Yan Zheng Dalin He |
| author_sort | Hengtong Fan |
| collection | DOAJ |
| description | Background: Acne is a chronic inflammatory skin disease. Photodynamic therapy (PDT) is a highly effective and safe drug-device combination treatment, typically using red and blue light. However, direct comparisons of aminolevulinic acid (ALA)-based PDT using these two light sources are lacking. Therefore, we compared the efficacy and adverse effects of ALA-based 450 nm blue laser-mediated PDT (BL-PDT) and 630 ± 10 nm red light-emitting diode-mediated PDT (RL-PDT) in the treatment of moderate-to-severe acne vulgaris, including analyses of different lesion types. Methods: Sixteen patients with moderate-to-severe acne vulgaris were recruited. All patients underwent BL-PDT on the left side of the face and RL-PDT on the right side. Treatments were administered thrice at 2-week intervals, and follow-up continued for 2 weeks after the final treatment. The average rates of improvement in inflammatory and non-inflammatory acne lesions, IGA (Investigator's Global Assessment) scales, and IGA success rates were calculated. In addition, adverse effects during and after each treatment were recorded. Results: At the 2-week follow-up after the final treatment, the average rates of improvement in total acne, inflammatory, and non-inflammatory lesions were 48.0 %, 63.0 %, and 30.0 % in the BL-PDT group and 42.2 %, 58.1 %, and 27.5 % in the RL-PDT group, respectively. The IGA scores for the two groups decreased by 1.8 and 1.7 points, respectively, and the IGA success rate was 53.3 % in both groups. There were no significant differences between the BL-PDT and RL-PDT groups in any measure of effectiveness. However, the BL-PDT group exhibited more severe adverse effects, especially pain and hyperpigmentation. Conclusions: BL-PDT and RL-PDT have similar efficacies in moderate-to-severe acne vulgaris and are particularly effective for inflammatory acne lesions. RL-PDT benefits from milder adverse effects than those of BL-PDT. |
| format | Article |
| id | doaj-art-04187417e34e440888d63a00746e4ffc |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-04187417e34e440888d63a00746e4ffc2025-08-20T01:48:03ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-10-014910432510.1016/j.pdpdt.2024.104325Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled studyHengtong Fan0Huihui Tuo1Yuhan Xie2Manyu Ju3Yan Sun4Yajie Yang5Xinnan Han6Zejun Ren7Yan Zheng8Dalin He9Department of Urology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Dermatology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Dermatology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Dermatology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Dermatology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Dermatology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Urology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Urology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, ChinaDepartment of Dermatology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, China; Corresponding authors.Department of Urology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, China; Corresponding authors.Background: Acne is a chronic inflammatory skin disease. Photodynamic therapy (PDT) is a highly effective and safe drug-device combination treatment, typically using red and blue light. However, direct comparisons of aminolevulinic acid (ALA)-based PDT using these two light sources are lacking. Therefore, we compared the efficacy and adverse effects of ALA-based 450 nm blue laser-mediated PDT (BL-PDT) and 630 ± 10 nm red light-emitting diode-mediated PDT (RL-PDT) in the treatment of moderate-to-severe acne vulgaris, including analyses of different lesion types. Methods: Sixteen patients with moderate-to-severe acne vulgaris were recruited. All patients underwent BL-PDT on the left side of the face and RL-PDT on the right side. Treatments were administered thrice at 2-week intervals, and follow-up continued for 2 weeks after the final treatment. The average rates of improvement in inflammatory and non-inflammatory acne lesions, IGA (Investigator's Global Assessment) scales, and IGA success rates were calculated. In addition, adverse effects during and after each treatment were recorded. Results: At the 2-week follow-up after the final treatment, the average rates of improvement in total acne, inflammatory, and non-inflammatory lesions were 48.0 %, 63.0 %, and 30.0 % in the BL-PDT group and 42.2 %, 58.1 %, and 27.5 % in the RL-PDT group, respectively. The IGA scores for the two groups decreased by 1.8 and 1.7 points, respectively, and the IGA success rate was 53.3 % in both groups. There were no significant differences between the BL-PDT and RL-PDT groups in any measure of effectiveness. However, the BL-PDT group exhibited more severe adverse effects, especially pain and hyperpigmentation. Conclusions: BL-PDT and RL-PDT have similar efficacies in moderate-to-severe acne vulgaris and are particularly effective for inflammatory acne lesions. RL-PDT benefits from milder adverse effects than those of BL-PDT.http://www.sciencedirect.com/science/article/pii/S1572100024003624AcnePhotodynamic therapyBlue laserRed light-emitting diodeAminolevulinic acid |
| spellingShingle | Hengtong Fan Huihui Tuo Yuhan Xie Manyu Ju Yan Sun Yajie Yang Xinnan Han Zejun Ren Yan Zheng Dalin He Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study Photodiagnosis and Photodynamic Therapy Acne Photodynamic therapy Blue laser Red light-emitting diode Aminolevulinic acid |
| title | Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study |
| title_full | Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study |
| title_fullStr | Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study |
| title_full_unstemmed | Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study |
| title_short | Comparison of blue laser and red light-emitting diode-mediated aminolevulinic acid-based photodynamic therapy for moderate and severe acne vulgaris: A prospective, split-face, nonrandomized controlled study |
| title_sort | comparison of blue laser and red light emitting diode mediated aminolevulinic acid based photodynamic therapy for moderate and severe acne vulgaris a prospective split face nonrandomized controlled study |
| topic | Acne Photodynamic therapy Blue laser Red light-emitting diode Aminolevulinic acid |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024003624 |
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