O-GlcNAcylation of NONO regulates paraspeckle component assembly and contributes to colon cancer cell proliferation

O-GlcNAcylation of NONO regulates paraspeckle component assembly and contributes to colon cancer cell proliferation

Abstract Non-POU domain-containing octamer-binding protein (NONO) is a multifunctional member of the Drosophila behavior/human splicing (DBHS) protein family with DNA- and RNA-binding activity. NONO is highly expressed in various types of cancer, and excessive O-GlcNAcylation has also been implicate...

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Main Authors: Yeolhoe Kim, Kyung-Tae Lee, Han Byeol Kim, Hyeryeon Jung, Jeong Yeon Ko, Tae Hyun Kweon, Hari Chandana Yadavalli, Junghwa Seo, Suena Ji, Yun Ju Kim, Donghyuk Shin, Seong Wook Yang, Myeong Min Lee, Jin Won Cho, Eugene C. Yi, Jin-Wu Nam, Won Ho Yang
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02405-z
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