Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer
Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (...
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2025-04-01
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| Series: | Chinese Journal of Lung Cancer |
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| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2025.102.15 |
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| author | Wangcheng CHEN Lili PANG Yuemei LAN Yanhong SHI Bingbing WEN Baihong ZHANG |
| author_facet | Wangcheng CHEN Lili PANG Yuemei LAN Yanhong SHI Bingbing WEN Baihong ZHANG |
| author_sort | Wangcheng CHEN |
| collection | DOAJ |
| description | Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape. |
| format | Article |
| id | doaj-art-0406f46cebea4d8fbc24e302093af1b7 |
| institution | DOAJ |
| issn | 1009-3419 1999-6187 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj-art-0406f46cebea4d8fbc24e302093af1b72025-08-20T03:13:32ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872025-04-0128431932410.3779/j.issn.1009-3419.2025.102.15Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung CancerWangcheng CHEN0Lili PANG1Yuemei LAN2Yanhong SHI3Bingbing WEN4Baihong ZHANG5Northwest Minzu University College of Medicine, Lanzhou 730050, ChinaDepartment of Oncology, the 940th Hospital of Joint Logistic Support Force
of Chinese People's Liberation Army, Lanzhou 730050, ChinaDepartment of Oncology, the 940th Hospital of Joint Logistic Support Force
of Chinese People's Liberation Army, Lanzhou 730050, ChinaNorthwest Minzu University College of Medicine, Lanzhou 730050, ChinaNorthwest Minzu University College of Medicine, Lanzhou 730050, ChinaDepartment of Oncology, the 940th Hospital of Joint Logistic Support Force
of Chinese People's Liberation Army, Lanzhou 730050, ChinaNon-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape.http://dx.doi.org/10.3779/j.issn.1009-3419.2025.102.15lung neoplasmszdhhc enzymesprotein palmitoylationimmune escapepd-l1 |
| spellingShingle | Wangcheng CHEN Lili PANG Yuemei LAN Yanhong SHI Bingbing WEN Baihong ZHANG Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer Chinese Journal of Lung Cancer lung neoplasms zdhhc enzymes protein palmitoylation immune escape pd-l1 |
| title | Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung Cancer |
| title_full | Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung Cancer |
| title_fullStr | Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung Cancer |
| title_full_unstemmed | Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung Cancer |
| title_short | Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung Cancer |
| title_sort | research progress and applications of zdhhc mediated protein palmitoylation
in the development and immune escape of non small cell lung cancer |
| topic | lung neoplasms zdhhc enzymes protein palmitoylation immune escape pd-l1 |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2025.102.15 |
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