Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study
Introduction: Saliva, a versatile biological fluid, has gained recognition as an invaluable medium for point-of-care diagnostics, offering insight into the complex dynamics of periodontal tissue inflammation. Aims: This study aimed to assess salivary lactoferrin (LF) concentration among individuals...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-08-01
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| Series: | Saudi Journal of Oral Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/sjoralsci.sjoralsci_35_24 |
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| author | Hattan Mohamed Arab Hassan Abed Arkadiusz Dziedzic Doaa Nadhim Mutaz Banjar Khalid Metwalli Mohsen Aljabri Marta Tanasiewicz |
| author_facet | Hattan Mohamed Arab Hassan Abed Arkadiusz Dziedzic Doaa Nadhim Mutaz Banjar Khalid Metwalli Mohsen Aljabri Marta Tanasiewicz |
| author_sort | Hattan Mohamed Arab |
| collection | DOAJ |
| description | Introduction:
Saliva, a versatile biological fluid, has gained recognition as an invaluable medium for point-of-care diagnostics, offering insight into the complex dynamics of periodontal tissue inflammation.
Aims:
This study aimed to assess salivary lactoferrin (LF) concentration among individuals diagnosed with periodontitis (PDS) compared to a control group.
Materials and Methods:
A randomized, observational study enrolled 441 participants residing in Southern Sweden, aged 20 and 89 years and diagnosed with PDS. Clinical examination was performed following a standardized periodontal protocol, measuring key periodontal parameters such as plaque index (PI), bleeding index (BI), periodontal pocket depth (PPD), and marginal alveolar bone level/bone loss using posterior intraoral bitewing radiographs. Stimulated saliva samples were analyzed for LF concentration using enzyme e-linked immunosorbent assay. Statistical analysis included Pearson correlation and ANOVA variance with a 95% confidence interval.
Results and Discussion:
We found no significant difference among the studied groups in mean salivary LF concentration (P > 0.05), whereas we observed a negative association between PI and salivary LF concentration (Pearson correlation = 0.110, P = 0.024), suggesting that increased plaque scores were associated with decreased LF level. In addition, smokers exhibited lower LF levels (P = 0.001). Notably, salivary LF concentration did not correlate with selected clinical parameters of PDS, including BI and PPD.
Conclusions:
These results underscore the multifaceted nature of salivary components and emphasize the need to consider various factors when evaluating the impact of PDS on saliva. Further research is imperative to validate risk factors contributing to the development of PDS and the diagnostic potential of salivary biomarkers, considering the intricate interplay between saliva and periodontal status. This study contributes valuable insight into the potential utility of saliva as a diagnostic medium. |
| format | Article |
| id | doaj-art-0406ae127afa44d697fcd87a7ea3f871 |
| institution | OA Journals |
| issn | 2542-7849 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Oral Sciences |
| spelling | doaj-art-0406ae127afa44d697fcd87a7ea3f8712025-08-20T02:09:48ZengWolters Kluwer Medknow PublicationsSaudi Journal of Oral Sciences2542-78492024-08-0111211612410.4103/sjoralsci.sjoralsci_35_24Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational studyHattan Mohamed ArabHassan AbedArkadiusz DziedzicDoaa NadhimMutaz BanjarKhalid MetwalliMohsen AljabriMarta TanasiewiczIntroduction: Saliva, a versatile biological fluid, has gained recognition as an invaluable medium for point-of-care diagnostics, offering insight into the complex dynamics of periodontal tissue inflammation. Aims: This study aimed to assess salivary lactoferrin (LF) concentration among individuals diagnosed with periodontitis (PDS) compared to a control group. Materials and Methods: A randomized, observational study enrolled 441 participants residing in Southern Sweden, aged 20 and 89 years and diagnosed with PDS. Clinical examination was performed following a standardized periodontal protocol, measuring key periodontal parameters such as plaque index (PI), bleeding index (BI), periodontal pocket depth (PPD), and marginal alveolar bone level/bone loss using posterior intraoral bitewing radiographs. Stimulated saliva samples were analyzed for LF concentration using enzyme e-linked immunosorbent assay. Statistical analysis included Pearson correlation and ANOVA variance with a 95% confidence interval. Results and Discussion: We found no significant difference among the studied groups in mean salivary LF concentration (P > 0.05), whereas we observed a negative association between PI and salivary LF concentration (Pearson correlation = 0.110, P = 0.024), suggesting that increased plaque scores were associated with decreased LF level. In addition, smokers exhibited lower LF levels (P = 0.001). Notably, salivary LF concentration did not correlate with selected clinical parameters of PDS, including BI and PPD. Conclusions: These results underscore the multifaceted nature of salivary components and emphasize the need to consider various factors when evaluating the impact of PDS on saliva. Further research is imperative to validate risk factors contributing to the development of PDS and the diagnostic potential of salivary biomarkers, considering the intricate interplay between saliva and periodontal status. This study contributes valuable insight into the potential utility of saliva as a diagnostic medium.https://journals.lww.com/10.4103/sjoralsci.sjoralsci_35_24bone lossgingival indexinflammationlactoferrinperiodontal diseaseperiodontal pocket depthperiodontitissalivasmoking |
| spellingShingle | Hattan Mohamed Arab Hassan Abed Arkadiusz Dziedzic Doaa Nadhim Mutaz Banjar Khalid Metwalli Mohsen Aljabri Marta Tanasiewicz Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study Saudi Journal of Oral Sciences bone loss gingival index inflammation lactoferrin periodontal disease periodontal pocket depth periodontitis saliva smoking |
| title | Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study |
| title_full | Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study |
| title_fullStr | Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study |
| title_full_unstemmed | Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study |
| title_short | Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study |
| title_sort | association between the concentration of salivary lactoferrin smoking and periodontal disease parameters a randomized observational study |
| topic | bone loss gingival index inflammation lactoferrin periodontal disease periodontal pocket depth periodontitis saliva smoking |
| url | https://journals.lww.com/10.4103/sjoralsci.sjoralsci_35_24 |
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