Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances
<b>Background:</b> New drugs for the treatment of protozoal parasite infections such as toxoplasmosis and leishmaniasis are required. Cinnamaldehyde and its derivatives appear to be promising antiparasitic drug candidates. <b>Methods:</b> Acyl hydrazones of cinnamaldehyde, 4-...
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2024-11-01
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| author | Ibrahim S. Al Nasr Waleed S. Koko Tariq A. Khan Rainer Schobert Bernhard Biersack |
| author_facet | Ibrahim S. Al Nasr Waleed S. Koko Tariq A. Khan Rainer Schobert Bernhard Biersack |
| author_sort | Ibrahim S. Al Nasr |
| collection | DOAJ |
| description | <b>Background:</b> New drugs for the treatment of protozoal parasite infections such as toxoplasmosis and leishmaniasis are required. Cinnamaldehyde and its derivatives appear to be promising antiparasitic drug candidates. <b>Methods:</b> Acyl hydrazones of cinnamaldehyde, 4-dimethylaminocinnamaldehyde, and of the synthetic fragrances silvial<sup>TM</sup> and florhydral<sup>TM</sup> were prepared and tested for activity against <i>Toxoplasma gondii</i> (<i>T. gondii</i>) and <i>Leishmania major</i> (<i>L. major</i>) parasites. <b>Results:</b> Three cinnamaldehyde acyl hydrazones (3-hydroxy-2-naphthoyl <b>2a</b> and the salicyloyls <b>2c</b> and <b>2d</b>) showed good activity against <i>T. gondii</i>, and two compounds derived from cinnamaldehyde and florhydral<sup>TM</sup> (3-hydroxy-2-naphthoyls <b>2a</b> and <b>4a</b>) exhibited moderate activity against <i>L. major</i> promastigotes. <b>Conclusions:</b> In particular, the identified antitoxoplasmal activities are promising and might lead to the development of new potent and cost-effective drug candidates for the therapy of toxoplasmosis. |
| format | Article |
| id | doaj-art-040449910f864f8da40f880e7cd9e2a4 |
| institution | DOAJ |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-11-01 |
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| series | Antibiotics |
| spelling | doaj-art-040449910f864f8da40f880e7cd9e2a42025-08-20T02:53:22ZengMDPI AGAntibiotics2079-63822024-11-011312111410.3390/antibiotics13121114Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related FragrancesIbrahim S. Al Nasr0Waleed S. Koko1Tariq A. Khan2Rainer Schobert3Bernhard Biersack4Department of Biology, College of Science, Qassim University, Qassim 51452, Saudi ArabiaDepartment of Biology, College of Science, Qassim University, Qassim 51452, Saudi ArabiaDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Qassim 51452, Saudi ArabiaOrganic Chemistry Laboratory, University Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, GermanyOrganic Chemistry Laboratory, University Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany<b>Background:</b> New drugs for the treatment of protozoal parasite infections such as toxoplasmosis and leishmaniasis are required. Cinnamaldehyde and its derivatives appear to be promising antiparasitic drug candidates. <b>Methods:</b> Acyl hydrazones of cinnamaldehyde, 4-dimethylaminocinnamaldehyde, and of the synthetic fragrances silvial<sup>TM</sup> and florhydral<sup>TM</sup> were prepared and tested for activity against <i>Toxoplasma gondii</i> (<i>T. gondii</i>) and <i>Leishmania major</i> (<i>L. major</i>) parasites. <b>Results:</b> Three cinnamaldehyde acyl hydrazones (3-hydroxy-2-naphthoyl <b>2a</b> and the salicyloyls <b>2c</b> and <b>2d</b>) showed good activity against <i>T. gondii</i>, and two compounds derived from cinnamaldehyde and florhydral<sup>TM</sup> (3-hydroxy-2-naphthoyls <b>2a</b> and <b>4a</b>) exhibited moderate activity against <i>L. major</i> promastigotes. <b>Conclusions:</b> In particular, the identified antitoxoplasmal activities are promising and might lead to the development of new potent and cost-effective drug candidates for the therapy of toxoplasmosis.https://www.mdpi.com/2079-6382/13/12/1114cinnamaldehydefragrancesacyl hydrazonesantiparasitic drugstoxoplasmosis<i>Toxoplasma gondii</i> |
| spellingShingle | Ibrahim S. Al Nasr Waleed S. Koko Tariq A. Khan Rainer Schobert Bernhard Biersack Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances Antibiotics cinnamaldehyde fragrances acyl hydrazones antiparasitic drugs toxoplasmosis <i>Toxoplasma gondii</i> |
| title | Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances |
| title_full | Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances |
| title_fullStr | Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances |
| title_full_unstemmed | Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances |
| title_short | Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances |
| title_sort | antiparasitic activities of acyl hydrazones from cinnamaldehydes and structurally related fragrances |
| topic | cinnamaldehyde fragrances acyl hydrazones antiparasitic drugs toxoplasmosis <i>Toxoplasma gondii</i> |
| url | https://www.mdpi.com/2079-6382/13/12/1114 |
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