Predictors of neuropsychiatric manifestations in pediatric patients with lupus.
Early detection of neuropsychiatric systemic lupus erythematosus (NPSLE) in children remains challenging in clinical settings. This study aims to describe the autoantibodies, organ disorders, the SLEDAI-2K score, and complement levels at the time of diagnosis in systemic lupus erythematosus (SLE) as...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0325915 |
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| author | Wei Jiang Xin Peng Liqun Dong Ling Wu Yazhen Di Li Lin |
| author_facet | Wei Jiang Xin Peng Liqun Dong Ling Wu Yazhen Di Li Lin |
| author_sort | Wei Jiang |
| collection | DOAJ |
| description | Early detection of neuropsychiatric systemic lupus erythematosus (NPSLE) in children remains challenging in clinical settings. This study aims to describe the autoantibodies, organ disorders, the SLEDAI-2K score, and complement levels at the time of diagnosis in systemic lupus erythematosus (SLE) as well as investigate the predictors of NPSLE. We reviewed medical records of hospitalized children with SLE (< 18 years old) and extracted information on clinical features, serum autoantibodies, and laboratory test results. Multivariable logistic regression was used to establish the predictors of NPSLE and SLE without neuropsychiatric manifestations. Results revealed that 22.8% of children with NPSLE had higher ANA levels and SLEDAI-2K scores, lower C4 levels, and greater AMA-M2, β2GPI Abs, Anti-Rib-P Ab, ANCA, and LAC positivity at SLE diagnosis. The predictors of NPSLE were β2GPI-Abs (OR = 4.603), anti-Rib-P Ab (OR = 4.153), and SLEDAI-2K score (OR = 1.215). In summary, the findings show that the SLEDAI-2K score, β2GPI-Abs, and anti-Rib-P Ab are predictors of NPSLE. |
| format | Article |
| id | doaj-art-0403a169f9bb4ff594eb13baa9ec6eed |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-0403a169f9bb4ff594eb13baa9ec6eed2025-08-20T03:45:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032591510.1371/journal.pone.0325915Predictors of neuropsychiatric manifestations in pediatric patients with lupus.Wei JiangXin PengLiqun DongLing WuYazhen DiLi LinEarly detection of neuropsychiatric systemic lupus erythematosus (NPSLE) in children remains challenging in clinical settings. This study aims to describe the autoantibodies, organ disorders, the SLEDAI-2K score, and complement levels at the time of diagnosis in systemic lupus erythematosus (SLE) as well as investigate the predictors of NPSLE. We reviewed medical records of hospitalized children with SLE (< 18 years old) and extracted information on clinical features, serum autoantibodies, and laboratory test results. Multivariable logistic regression was used to establish the predictors of NPSLE and SLE without neuropsychiatric manifestations. Results revealed that 22.8% of children with NPSLE had higher ANA levels and SLEDAI-2K scores, lower C4 levels, and greater AMA-M2, β2GPI Abs, Anti-Rib-P Ab, ANCA, and LAC positivity at SLE diagnosis. The predictors of NPSLE were β2GPI-Abs (OR = 4.603), anti-Rib-P Ab (OR = 4.153), and SLEDAI-2K score (OR = 1.215). In summary, the findings show that the SLEDAI-2K score, β2GPI-Abs, and anti-Rib-P Ab are predictors of NPSLE.https://doi.org/10.1371/journal.pone.0325915 |
| spellingShingle | Wei Jiang Xin Peng Liqun Dong Ling Wu Yazhen Di Li Lin Predictors of neuropsychiatric manifestations in pediatric patients with lupus. PLoS ONE |
| title | Predictors of neuropsychiatric manifestations in pediatric patients with lupus. |
| title_full | Predictors of neuropsychiatric manifestations in pediatric patients with lupus. |
| title_fullStr | Predictors of neuropsychiatric manifestations in pediatric patients with lupus. |
| title_full_unstemmed | Predictors of neuropsychiatric manifestations in pediatric patients with lupus. |
| title_short | Predictors of neuropsychiatric manifestations in pediatric patients with lupus. |
| title_sort | predictors of neuropsychiatric manifestations in pediatric patients with lupus |
| url | https://doi.org/10.1371/journal.pone.0325915 |
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