18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom
Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation. Longitudinal preclinical studies with five or more image procedures, involving radiopharmaceuticals injection and/or X-radiation, are no...
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| Format: | Article |
| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2022-12-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2089 |
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| author | Andréa Vidal Ferreira Ana Carolina Araujo Bispo Christiane Silva Leite Juliana Batista da Silva Marcelo Mamede Rodrigo Modesto Gadelha Gontijo Bruno Melo Mendes |
| author_facet | Andréa Vidal Ferreira Ana Carolina Araujo Bispo Christiane Silva Leite Juliana Batista da Silva Marcelo Mamede Rodrigo Modesto Gadelha Gontijo Bruno Melo Mendes |
| author_sort | Andréa Vidal Ferreira |
| collection | DOAJ |
| description | Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation. Longitudinal preclinical studies with five or more image procedures, involving radiopharmaceuticals injection and/or X-radiation, are not uncommon. However, a suitable dosimetric evaluation is not always available and, sometimes, absorbed doses in animal organs or tissues and their influence in experimental results were not appropriately taken into account. Accurate calculation of absorbed doses in mice organs are needed to evaluate potential radiobiological effects that may interfere with in vivo experiments. In this work, we perform a preliminary 16α-[18F]-fluoro-17β-estradiol (18F-FES) radiation dosimetry estimates for female mice. The obtained animal dosimetric results can be useful for evaluating animal doses during the design of longitudinal preclinical studies. |
| format | Article |
| id | doaj-art-03fe8e7c79a14cd09feb1f3d7b2b907a |
| institution | OA Journals |
| issn | 2319-0612 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-03fe8e7c79a14cd09feb1f3d7b2b907a2025-08-20T02:39:08ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122022-12-0110411210.15392/2319-0612.2022.2089170718F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantomAndréa Vidal Ferreira0https://orcid.org/0000-0001-7698-4323Ana Carolina Araujo Bispo1https://orcid.org/0000-0002-1934-9881Christiane Silva Leite2https://orcid.org/0000-0003-3336-8912Juliana Batista da Silva3https://orcid.org/0000-0002-0794-1896Marcelo Mamede4https://orcid.org/0000-0001-5818-0954Rodrigo Modesto Gadelha Gontijo5Bruno Melo Mendes6https://orcid.org/0000-0002-8914-8022Centro de Desenvolvimento da Tecnologia Nuclear CDTN/CNENCentro de Desenvolvimento da Tecnologia NuclearCentro de Desenvolvimento da Tecnologia NuclearCentro de Desenvolvimento da Tecnologia NuclearUniversidade Federal de Minas Gerais (UFMG)Universidade Federal de Minas Gerais (UFMG)Centro de Desenvolvimento da Tecnologia NuclearSmall animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation. Longitudinal preclinical studies with five or more image procedures, involving radiopharmaceuticals injection and/or X-radiation, are not uncommon. However, a suitable dosimetric evaluation is not always available and, sometimes, absorbed doses in animal organs or tissues and their influence in experimental results were not appropriately taken into account. Accurate calculation of absorbed doses in mice organs are needed to evaluate potential radiobiological effects that may interfere with in vivo experiments. In this work, we perform a preliminary 16α-[18F]-fluoro-17β-estradiol (18F-FES) radiation dosimetry estimates for female mice. The obtained animal dosimetric results can be useful for evaluating animal doses during the design of longitudinal preclinical studies.https://bjrs.org.br/revista/index.php/REVISTA/article/view/2089radiation dosimetry,18f-fespreclinical studies |
| spellingShingle | Andréa Vidal Ferreira Ana Carolina Araujo Bispo Christiane Silva Leite Juliana Batista da Silva Marcelo Mamede Rodrigo Modesto Gadelha Gontijo Bruno Melo Mendes 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom Brazilian Journal of Radiation Sciences radiation dosimetry, 18f-fes preclinical studies |
| title | 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom |
| title_full | 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom |
| title_fullStr | 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom |
| title_full_unstemmed | 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom |
| title_short | 18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom |
| title_sort | 18f fes radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom |
| topic | radiation dosimetry, 18f-fes preclinical studies |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2089 |
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