Clinical and Pathological Roles of Ro/SSA Autoantibody System
Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/606195 |
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| _version_ | 1832564587517444096 |
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| author | Ryusuke Yoshimi Atsuhisa Ueda Keiko Ozato Yoshiaki Ishigatsubo |
| author_facet | Ryusuke Yoshimi Atsuhisa Ueda Keiko Ozato Yoshiaki Ishigatsubo |
| author_sort | Ryusuke Yoshimi |
| collection | DOAJ |
| description | Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases. |
| format | Article |
| id | doaj-art-03f7bf905e0848abbe7f6879790407f6 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-03f7bf905e0848abbe7f6879790407f62025-02-03T01:10:33ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/606195606195Clinical and Pathological Roles of Ro/SSA Autoantibody SystemRyusuke Yoshimi0Atsuhisa Ueda1Keiko Ozato2Yoshiaki Ishigatsubo3Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanDepartment of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanProgram in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USADepartment of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanAnti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.http://dx.doi.org/10.1155/2012/606195 |
| spellingShingle | Ryusuke Yoshimi Atsuhisa Ueda Keiko Ozato Yoshiaki Ishigatsubo Clinical and Pathological Roles of Ro/SSA Autoantibody System Clinical and Developmental Immunology |
| title | Clinical and Pathological Roles of Ro/SSA Autoantibody System |
| title_full | Clinical and Pathological Roles of Ro/SSA Autoantibody System |
| title_fullStr | Clinical and Pathological Roles of Ro/SSA Autoantibody System |
| title_full_unstemmed | Clinical and Pathological Roles of Ro/SSA Autoantibody System |
| title_short | Clinical and Pathological Roles of Ro/SSA Autoantibody System |
| title_sort | clinical and pathological roles of ro ssa autoantibody system |
| url | http://dx.doi.org/10.1155/2012/606195 |
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