Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study
Background: Pituitary macroadenoma is a global health concern. Advanced imaging techniques, such as multiparametric magnetic resonance imaging (MRI), have emerged as valuable tools for comprehensively evaluating macroadenomas. This study aimed to evaluate the association between multiparametric MRI...
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Shahid Beheshti University of Medical Sciences
2025-07-01
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| Series: | Novelty in Biomedicine |
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| Online Access: | https://journals.sbmu.ac.ir/nbm/article/view/46701 |
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| author | Maryam Haghighi-Morad Farahnaz Bidari Zerehpoosh Mohammad Amin Jahangiriyan |
| author_facet | Maryam Haghighi-Morad Farahnaz Bidari Zerehpoosh Mohammad Amin Jahangiriyan |
| author_sort | Maryam Haghighi-Morad |
| collection | DOAJ |
| description | Background: Pituitary macroadenoma is a global health concern. Advanced imaging techniques, such as multiparametric magnetic resonance imaging (MRI), have emerged as valuable tools for comprehensively evaluating macroadenomas. This study aimed to evaluate the association between multiparametric MRI findings, pathological features, and type of secretion in patients with pituitary macroadenoma.
Materials and Methods: This cross-sectional study evaluated the association between multiparametric MRI findings and pathological features in patients with pituitary macroadenoma. Patients with pituitary macroadenoma referred to Loghman Hakim Hospital (Tehran-Iran) in 2023 were assessed. Preoperative MRI, including T1W, T2W, DWI, ADC, and CE-MRI, were evaluated for signal intensity, maximum diameter, and tumoral extension. The association between the results of MR imaging and the pathologic findings of the resected macroadenoma was assessed.
Results: Forty-five patients were assessed. The mean age was 48.22 ± 14.58 years, and 55.6% of the patients were male. Most patients (48.9%) had isointense lesion in T1W, and most lesions (57.8%) had heterogeneous signals in T2W. Apparent diffusion coefficient levels (ADC) had no diagnostic value for predicting pathologic subtypes. The most invasion was to the infrasellar among macro adenomas (P-value: 0.037). Among patients with gonadotroph pathology results, invasion to the third ventricle with heterogeneous signal on T2 was more common (P-values<0.05). The mean tumor volume is higher in the Prolactin (PRL) secreting type compared to other categories (P-value: 0.002).
Conclusion: Multiparametric MRI helps predict the pathological diagnosis of pituitary macroadenoma. |
| format | Article |
| id | doaj-art-03f2ea09b20d4137ada02a13e81df0d1 |
| institution | Kabale University |
| issn | 2345-3907 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Novelty in Biomedicine |
| spelling | doaj-art-03f2ea09b20d4137ada02a13e81df0d12025-08-20T03:59:08ZengShahid Beheshti University of Medical SciencesNovelty in Biomedicine2345-39072025-07-0113314415110.22037/nbm.v13i3.4670136602Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive StudyMaryam Haghighi-Morad0Farahnaz Bidari Zerehpoosh1Mohammad Amin Jahangiriyan21Department of Radiology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran2Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran1Department of Radiology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: Pituitary macroadenoma is a global health concern. Advanced imaging techniques, such as multiparametric magnetic resonance imaging (MRI), have emerged as valuable tools for comprehensively evaluating macroadenomas. This study aimed to evaluate the association between multiparametric MRI findings, pathological features, and type of secretion in patients with pituitary macroadenoma. Materials and Methods: This cross-sectional study evaluated the association between multiparametric MRI findings and pathological features in patients with pituitary macroadenoma. Patients with pituitary macroadenoma referred to Loghman Hakim Hospital (Tehran-Iran) in 2023 were assessed. Preoperative MRI, including T1W, T2W, DWI, ADC, and CE-MRI, were evaluated for signal intensity, maximum diameter, and tumoral extension. The association between the results of MR imaging and the pathologic findings of the resected macroadenoma was assessed. Results: Forty-five patients were assessed. The mean age was 48.22 ± 14.58 years, and 55.6% of the patients were male. Most patients (48.9%) had isointense lesion in T1W, and most lesions (57.8%) had heterogeneous signals in T2W. Apparent diffusion coefficient levels (ADC) had no diagnostic value for predicting pathologic subtypes. The most invasion was to the infrasellar among macro adenomas (P-value: 0.037). Among patients with gonadotroph pathology results, invasion to the third ventricle with heterogeneous signal on T2 was more common (P-values<0.05). The mean tumor volume is higher in the Prolactin (PRL) secreting type compared to other categories (P-value: 0.002). Conclusion: Multiparametric MRI helps predict the pathological diagnosis of pituitary macroadenoma.https://journals.sbmu.ac.ir/nbm/article/view/46701adenomapituitary tumormultiparametric magnetic resonance imagingpathologyhormone secretionmacroadenomaadc |
| spellingShingle | Maryam Haghighi-Morad Farahnaz Bidari Zerehpoosh Mohammad Amin Jahangiriyan Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study Novelty in Biomedicine adenoma pituitary tumor multiparametric magnetic resonance imaging pathology hormone secretion macroadenoma adc |
| title | Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study |
| title_full | Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study |
| title_fullStr | Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study |
| title_full_unstemmed | Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study |
| title_short | Multiparametric MRI Findings association with Pathological Features and hormonal secretion in Patients with Pituitary Macroadenoma: A Comprehensive Study |
| title_sort | multiparametric mri findings association with pathological features and hormonal secretion in patients with pituitary macroadenoma a comprehensive study |
| topic | adenoma pituitary tumor multiparametric magnetic resonance imaging pathology hormone secretion macroadenoma adc |
| url | https://journals.sbmu.ac.ir/nbm/article/view/46701 |
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