Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis

Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis

Background Hypoxia is associated with the evasion of triple-negative breast cancer (TNBC) from immune surveillance. Hypoxia increases the subpopulation of putative TNBC stem-like cells (TNBCSCs) through activating Wnt/β-Catenin signaling. The shedding of MHC class I-related chain A (MICA) is particu...

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Main Authors: Lin Yang, Tong Wang, Wei Xie, Jin Wang, Jing Xu, Hao Yang, Gang Huang, Haiyan Xie, Xiaofei Zhang, Danfang Li, Xingxing Li, Qingqing Huang, Chenyue Wang, Lisha Wu, Shuyang Mao, Zitong Wang, Yuxia Liu
Format: Article
Language:English
Published: BMJ Publishing Group 2025-02-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/2/e009621.full
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