Inflammasome in Intestinal Inflammation and Cancer
The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of impo...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/654963 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553309555130368 |
|---|---|
| author | Tiago Nunes Heitor S. de Souza |
| author_facet | Tiago Nunes Heitor S. de Souza |
| author_sort | Tiago Nunes |
| collection | DOAJ |
| description | The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens. |
| format | Article |
| id | doaj-art-03eabf527e724300b9866f38f63723ec |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-03eabf527e724300b9866f38f63723ec2025-02-03T05:54:13ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/654963654963Inflammasome in Intestinal Inflammation and CancerTiago Nunes0Heitor S. de Souza1Biofunctionality Unit, ZIEL Research Center for Nutrition and Food Sciences, Technical University of Munich, 85354 Freising-Weihenstephan, GermanyServiço de Gastroenterologia & Laboratório Multidisciplinar de Pesquisa, Hospital Universitario, Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, BrazilThe activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response. In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.http://dx.doi.org/10.1155/2013/654963 |
| spellingShingle | Tiago Nunes Heitor S. de Souza Inflammasome in Intestinal Inflammation and Cancer Mediators of Inflammation |
| title | Inflammasome in Intestinal Inflammation and Cancer |
| title_full | Inflammasome in Intestinal Inflammation and Cancer |
| title_fullStr | Inflammasome in Intestinal Inflammation and Cancer |
| title_full_unstemmed | Inflammasome in Intestinal Inflammation and Cancer |
| title_short | Inflammasome in Intestinal Inflammation and Cancer |
| title_sort | inflammasome in intestinal inflammation and cancer |
| url | http://dx.doi.org/10.1155/2013/654963 |
| work_keys_str_mv | AT tiagonunes inflammasomeinintestinalinflammationandcancer AT heitorsdesouza inflammasomeinintestinalinflammationandcancer |