Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review
Periodontitis has turned into a general oral disease defined by chronic inflammation of the gums and helping tissues of the teeth. It dramatically influences both oral and systemic health and is a main trigger of tooth loss. Periodontitis is tightly linked to oxidative stress, and evidence reveals t...
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| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1485367/full |
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| author | Wei Liu Wei Liu Daoyu Guo |
| author_facet | Wei Liu Wei Liu Daoyu Guo |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | Periodontitis has turned into a general oral disease defined by chronic inflammation of the gums and helping tissues of the teeth. It dramatically influences both oral and systemic health and is a main trigger of tooth loss. Periodontitis is tightly linked to oxidative stress, and evidence reveals the utilization of certain antioxidants in related treatments. Our review delves into literature in periodontitis, centering on the latest therapeutic strategies and mechanistic evidences. This review starts by depicting the epidemiological features and pathogenic mechanisms of periodontitis, highlighting the vital mechanism of microbial community modefications, host immune responses, and genetic factors in disease development. Existing treatment approaches for periodontitis involve mechanical cleaning, antibiotic therapy, surgical interventions, and pharmacological treatments, with a comprehensive exploration on the strengths and limitations of each strategy and their related clinical utilizations. Besides, this review investigates emerging therapies, like anti-inflammatory treatments, immune modulation therapies, and biotechnological utilization in the control of periodontitis. It particularly stresses the protective effects of antioxidants and their mechanistic researches in periodontitis, highlighting their potential in slowing inflammatory responses and boosting tissue repair. Ultimately, our review intends to the concept of individual therapy and investigates future directions, comprising the utilization of precision medicine in periodontitis control and the individual design of treatment utilization. |
| format | Article |
| id | doaj-art-03e50ab9ae9343d9ba6ff943ca5f5048 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-03e50ab9ae9343d9ba6ff943ca5f50482025-08-20T03:08:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-05-011610.3389/fphys.2025.14853671485367Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative reviewWei Liu0Wei Liu1Daoyu Guo2School of Clinical Medicine, Qilu Medical University, Zibo, ChinaSchool of Medicine and Nursing, Huzhou University, Huzhou, ChinaSchool of Clinical Medicine, Qilu Medical University, Zibo, ChinaPeriodontitis has turned into a general oral disease defined by chronic inflammation of the gums and helping tissues of the teeth. It dramatically influences both oral and systemic health and is a main trigger of tooth loss. Periodontitis is tightly linked to oxidative stress, and evidence reveals the utilization of certain antioxidants in related treatments. Our review delves into literature in periodontitis, centering on the latest therapeutic strategies and mechanistic evidences. This review starts by depicting the epidemiological features and pathogenic mechanisms of periodontitis, highlighting the vital mechanism of microbial community modefications, host immune responses, and genetic factors in disease development. Existing treatment approaches for periodontitis involve mechanical cleaning, antibiotic therapy, surgical interventions, and pharmacological treatments, with a comprehensive exploration on the strengths and limitations of each strategy and their related clinical utilizations. Besides, this review investigates emerging therapies, like anti-inflammatory treatments, immune modulation therapies, and biotechnological utilization in the control of periodontitis. It particularly stresses the protective effects of antioxidants and their mechanistic researches in periodontitis, highlighting their potential in slowing inflammatory responses and boosting tissue repair. Ultimately, our review intends to the concept of individual therapy and investigates future directions, comprising the utilization of precision medicine in periodontitis control and the individual design of treatment utilization.https://www.frontiersin.org/articles/10.3389/fphys.2025.1485367/fulloxidative stressperiodontitisantioxidantsinflammationtissue repair |
| spellingShingle | Wei Liu Wei Liu Daoyu Guo Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review Frontiers in Physiology oxidative stress periodontitis antioxidants inflammation tissue repair |
| title | Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review |
| title_full | Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review |
| title_fullStr | Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review |
| title_full_unstemmed | Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review |
| title_short | Oxidative stress in periodontitis and the application of antioxidants in treatment: a narrative review |
| title_sort | oxidative stress in periodontitis and the application of antioxidants in treatment a narrative review |
| topic | oxidative stress periodontitis antioxidants inflammation tissue repair |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1485367/full |
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