Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin
The objective of this study was to create an antibiogram representative of bacterial skin infections in canine patients that would typically be treated empirically, i.e., without risk factors for antibiotic resistance, such as a history of recent antibiotic use, antibiotic treatment failure, or recu...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1512582/full |
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| author | W. Cooper Brookshire Larry D. Ballard Vernon C. Langston Joo Youn Park Keun-Seok Seo |
| author_facet | W. Cooper Brookshire Larry D. Ballard Vernon C. Langston Joo Youn Park Keun-Seok Seo |
| author_sort | W. Cooper Brookshire |
| collection | DOAJ |
| description | The objective of this study was to create an antibiogram representative of bacterial skin infections in canine patients that would typically be treated empirically, i.e., without risk factors for antibiotic resistance, such as a history of recent antibiotic use, antibiotic treatment failure, or recurrent infections. Traditional antibiograms are a form of passive surveillance and report antibiotic susceptibility of isolates from a specific laboratory, hospital, or region for a given period of time. However, traditional antibiograms are biased towards more resistance, because infections that have antibiotic susceptibility tests are more likely to be resistant, due to risk factors such as recent antibiotic treatment, hospitalization, or a history of previous antibiotic-resistant infections. Antibiotic susceptibility testing was performed on 67 pathogenic canine staphylococcal isolates (62 Staphylococcus pseudintermedius and 5 Staphylococcus schleiferi) from patients who met the study inclusion criteria, and 100% of isolates were susceptible to antibiotics commonly prescribed for canine staphylococcal skin infections, including clindamycin. Additionally, a subset of 49 isolates were also susceptible to chlorhexidine. The isolates were susceptible to a very low concentration of chlorhexidine, which supports its use as a preferred topical treatment. These data strongly indicate that dogs without a history of recent antibiotic use, treatment failure, or recurrent infections that present with bacterial skin infections are at low risk of antibiotic resistance. If systemic antibiotics are indicated in these patients with this clinical history and presentation, clindamycin should be considered as first-line therapy, owing to its 100% susceptibility in this antibiogram and less selection pressure for antibiotic resistant bacteria, compared to alternatives such as cephalosporins. |
| format | Article |
| id | doaj-art-03e0535ca87d4a7d8b2a10d0d438ece0 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj-art-03e0535ca87d4a7d8b2a10d0d438ece02025-02-10T06:48:30ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-02-011110.3389/fvets.2024.15125821512582Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycinW. Cooper Brookshire0Larry D. Ballard1Vernon C. Langston2Joo Youn Park3Keun-Seok Seo4Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United StatesDepartment of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United StatesDepartment of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United StatesDepartment of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United StatesDepartment of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United StatesThe objective of this study was to create an antibiogram representative of bacterial skin infections in canine patients that would typically be treated empirically, i.e., without risk factors for antibiotic resistance, such as a history of recent antibiotic use, antibiotic treatment failure, or recurrent infections. Traditional antibiograms are a form of passive surveillance and report antibiotic susceptibility of isolates from a specific laboratory, hospital, or region for a given period of time. However, traditional antibiograms are biased towards more resistance, because infections that have antibiotic susceptibility tests are more likely to be resistant, due to risk factors such as recent antibiotic treatment, hospitalization, or a history of previous antibiotic-resistant infections. Antibiotic susceptibility testing was performed on 67 pathogenic canine staphylococcal isolates (62 Staphylococcus pseudintermedius and 5 Staphylococcus schleiferi) from patients who met the study inclusion criteria, and 100% of isolates were susceptible to antibiotics commonly prescribed for canine staphylococcal skin infections, including clindamycin. Additionally, a subset of 49 isolates were also susceptible to chlorhexidine. The isolates were susceptible to a very low concentration of chlorhexidine, which supports its use as a preferred topical treatment. These data strongly indicate that dogs without a history of recent antibiotic use, treatment failure, or recurrent infections that present with bacterial skin infections are at low risk of antibiotic resistance. If systemic antibiotics are indicated in these patients with this clinical history and presentation, clindamycin should be considered as first-line therapy, owing to its 100% susceptibility in this antibiogram and less selection pressure for antibiotic resistant bacteria, compared to alternatives such as cephalosporins.https://www.frontiersin.org/articles/10.3389/fvets.2024.1512582/fullveterinaryantibiogramStaphylococcus pseudintermediusS. schleiferi antibiotic resistancebacterial folliculitispyoderma |
| spellingShingle | W. Cooper Brookshire Larry D. Ballard Vernon C. Langston Joo Youn Park Keun-Seok Seo Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin Frontiers in Veterinary Science veterinary antibiogram Staphylococcus pseudintermedius S. schleiferi antibiotic resistance bacterial folliculitis pyoderma |
| title | Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin |
| title_full | Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin |
| title_fullStr | Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin |
| title_full_unstemmed | Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin |
| title_short | Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin |
| title_sort | staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100 susceptible to clindamycin |
| topic | veterinary antibiogram Staphylococcus pseudintermedius S. schleiferi antibiotic resistance bacterial folliculitis pyoderma |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1512582/full |
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