Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities
This review explores the significance and prospects of using diverse T-cell variants in the context of combined therapy for lung cancer treatment. Recently, there has been an increase in research focused on understanding the critical role of tumor-specific T lymphocytes and the potential benefits of...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Advances in Respiratory Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2543-6031/92/6/45 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850059275479547904 |
|---|---|
| author | Anastasia Ganina Manarbek Askarov Larissa Kozina Madina Karimova Yerzhan Shayakhmetov Perizat Mukhamedzhanova Aigul Brimova Daulet Berikbol Elmira Chuvakova Lina Zaripova Abay Baigenzhin |
| author_facet | Anastasia Ganina Manarbek Askarov Larissa Kozina Madina Karimova Yerzhan Shayakhmetov Perizat Mukhamedzhanova Aigul Brimova Daulet Berikbol Elmira Chuvakova Lina Zaripova Abay Baigenzhin |
| author_sort | Anastasia Ganina |
| collection | DOAJ |
| description | This review explores the significance and prospects of using diverse T-cell variants in the context of combined therapy for lung cancer treatment. Recently, there has been an increase in research focused on understanding the critical role of tumor-specific T lymphocytes and the potential benefits of autologous T-cell-based treatments for individuals with lung cancer. One promising approach involves intravenous administration of ex vivo-activated autologous lymphocytes to improve the immune status of patients with cancer. Investigations are also exploring the factors that influence the success of T-cell therapy and the methods used to stimulate them. Achieving a comprehensive understanding of the characteristics of activated lymphocytes and deciphering the mechanisms underlying their activation of innate anti-tumor immunity will pave the way for numerous clinical trials and the development of innovative strategies for cancer therapy like combined immunotherapy and radiation therapy. |
| format | Article |
| id | doaj-art-03dfbacc8ce14728955fbb1fd7a4c1f2 |
| institution | DOAJ |
| issn | 2543-6031 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Advances in Respiratory Medicine |
| spelling | doaj-art-03dfbacc8ce14728955fbb1fd7a4c1f22025-08-20T02:50:56ZengMDPI AGAdvances in Respiratory Medicine2543-60312024-12-0192650452510.3390/arm92060045Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer ModalitiesAnastasia Ganina0Manarbek Askarov1Larissa Kozina2Madina Karimova3Yerzhan Shayakhmetov4Perizat Mukhamedzhanova5Aigul Brimova6Daulet Berikbol7Elmira Chuvakova8Lina Zaripova9Abay Baigenzhin10JSC National Scientific Medical Center, Astana 010009, KazakhstanJSC National Scientific Medical Center, Astana 010009, KazakhstanJSC National Scientific Medical Center, Astana 010009, KazakhstanJSC National Scientific Medical Center, Astana 010009, KazakhstanInternational Oncological Tomotherapy Center “YMIT”, Astana 010009, KazakhstanInternational Oncological Tomotherapy Center “YMIT”, Astana 010009, KazakhstanInternational Oncological Tomotherapy Center “YMIT”, Astana 010009, KazakhstanInternational Oncological Tomotherapy Center “YMIT”, Astana 010009, KazakhstanJSC National Scientific Medical Center, Astana 010009, KazakhstanJSC National Scientific Medical Center, Astana 010009, KazakhstanJSC National Scientific Medical Center, Astana 010009, KazakhstanThis review explores the significance and prospects of using diverse T-cell variants in the context of combined therapy for lung cancer treatment. Recently, there has been an increase in research focused on understanding the critical role of tumor-specific T lymphocytes and the potential benefits of autologous T-cell-based treatments for individuals with lung cancer. One promising approach involves intravenous administration of ex vivo-activated autologous lymphocytes to improve the immune status of patients with cancer. Investigations are also exploring the factors that influence the success of T-cell therapy and the methods used to stimulate them. Achieving a comprehensive understanding of the characteristics of activated lymphocytes and deciphering the mechanisms underlying their activation of innate anti-tumor immunity will pave the way for numerous clinical trials and the development of innovative strategies for cancer therapy like combined immunotherapy and radiation therapy.https://www.mdpi.com/2543-6031/92/6/45lymphocyteslung canceractivationtumorimmunotherapyimmunosuppression |
| spellingShingle | Anastasia Ganina Manarbek Askarov Larissa Kozina Madina Karimova Yerzhan Shayakhmetov Perizat Mukhamedzhanova Aigul Brimova Daulet Berikbol Elmira Chuvakova Lina Zaripova Abay Baigenzhin Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities Advances in Respiratory Medicine lymphocytes lung cancer activation tumor immunotherapy immunosuppression |
| title | Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities |
| title_full | Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities |
| title_fullStr | Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities |
| title_full_unstemmed | Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities |
| title_short | Prospects for Treatment of Lung Cancer Using Activated Lymphocytes Combined with Other Anti-Cancer Modalities |
| title_sort | prospects for treatment of lung cancer using activated lymphocytes combined with other anti cancer modalities |
| topic | lymphocytes lung cancer activation tumor immunotherapy immunosuppression |
| url | https://www.mdpi.com/2543-6031/92/6/45 |
| work_keys_str_mv | AT anastasiaganina prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT manarbekaskarov prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT larissakozina prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT madinakarimova prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT yerzhanshayakhmetov prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT perizatmukhamedzhanova prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT aigulbrimova prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT dauletberikbol prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT elmirachuvakova prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT linazaripova prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities AT abaybaigenzhin prospectsfortreatmentoflungcancerusingactivatedlymphocytescombinedwithotheranticancermodalities |