The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice
The purpose of this study was to determine the some toxicokinetic parameters of cyanide and thiocyanate in mice experimentally poisoned with sodium cyanide. In the study, 200 mice, 40-50 g weights, were used. Sodium cyanide were given intraperitoneally in doses of 0,1, 0.2, 0.4 and 0.8 mg/kg. Then,...
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Selcuk University Press
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| author | Sadettin Tanyıldızı İbrahim Pirinçci Sezai Kaya Bünyamin Traş Ender Yersan |
| author_facet | Sadettin Tanyıldızı İbrahim Pirinçci Sezai Kaya Bünyamin Traş Ender Yersan |
| author_sort | Sadettin Tanyıldızı |
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| description | The purpose of this study was to determine the some toxicokinetic parameters of cyanide and thiocyanate in mice experimentally poisoned with sodium cyanide. In the study, 200 mice, 40-50 g weights, were used. Sodium cyanide were given intraperitoneally in doses of 0,1, 0.2, 0.4 and 0.8 mg/kg. Then, some toxicokinetic parameters of the cyanide and thiocyanate like as distribution half-life, elimination half-life, mean existence lime and area under the curve (AUC) in the blood samples drawn at 6, 12, 30, 60, 120, 240, 360 ve 720th minutes were determined. The distribution half-lifes ol blood cyanide levels were, respectively, 0.04±0.02, 0.05±0.009. 0.06±0.008 and 0.08±0.01th hour; the elimination half-lifes were, respectively, 3.06±0.14, 2.36±0.02, 2.33±0.03 and 2.28±0.06 hours; the duration of maximal concentration was 12 minutes and the maximal blood levels, according to doses, respectively, were 0.153, 0.308, 0.350 and 0.376 µ,g/ml. Besides. mean existence times were, respectively, 4.53±0.20, 3.50±0.03, 3.46±0.05 and 3.43±0.12 hours and AUC values according to doses were, respectively, 33.50±2.62, 45.40±1.84, 48.91±2.77 and 58.47±2.54 µg.hour/ml were observed. The distribution half-lifes of blood thiocyanate levels were, respectively, 0.07±0.008, 0.09±0.005, 0.09±0.005 and 0.18±0.05 hours; the elimination hall-lifes were, respectively, 62.80±19.36, 25.79±2.65, 14.48±0.41 and 14.53±0.80 hours; the duration of maximal concentration 120 minutes and the maximal blood levels according to doses were, respectively, 0.265, 0246, 0.408 and 0.444 µg/ml. Besides, mean existence times were, respectively, 90.27±27.95, 37.37±3.83, 21.04±0.59 and 21.27±1.17 hours and AUC values according to doses were, respectively, 79.13±54.19, 28.06±15.38, 8.92±0.45 and 89.22±49.91 µg.hour/ml. |
| format | Article |
| id | doaj-art-03deecae581b4582a0993501eb9072f8 |
| institution | DOAJ |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
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| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-03deecae581b4582a0993501eb9072f82025-08-20T02:44:22ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19531414146481The investigation of toxicokinetics parameters of cyanide and thiocyanate in miceSadettin Tanyıldızı0İbrahim Pirinçci1Sezai Kaya2Bünyamin Traş3Ender Yersan4F.Ü. Veteriner Fakültesi, Farmakoloji Toksikoloji Anabilim Dalı, ELAZIĞF.Ü. Veteriner Fakültesi, Farmakoloji Toksikoloji Anabilim Dalı, ELAZIĞAÜ Veteriner Fakültesi. Farmakoloji Toksikoloji Anabilim Dalı, ANKARAS.Ü. Veteriner Fakültesi, Farmakoloji Toksikoloji Anabilim Dalı, ANKARAAÜ Veteriner Fakültesi. Farmakoloji Toksikoloji Anabilim Dalı, ANKARAThe purpose of this study was to determine the some toxicokinetic parameters of cyanide and thiocyanate in mice experimentally poisoned with sodium cyanide. In the study, 200 mice, 40-50 g weights, were used. Sodium cyanide were given intraperitoneally in doses of 0,1, 0.2, 0.4 and 0.8 mg/kg. Then, some toxicokinetic parameters of the cyanide and thiocyanate like as distribution half-life, elimination half-life, mean existence lime and area under the curve (AUC) in the blood samples drawn at 6, 12, 30, 60, 120, 240, 360 ve 720th minutes were determined. The distribution half-lifes ol blood cyanide levels were, respectively, 0.04±0.02, 0.05±0.009. 0.06±0.008 and 0.08±0.01th hour; the elimination half-lifes were, respectively, 3.06±0.14, 2.36±0.02, 2.33±0.03 and 2.28±0.06 hours; the duration of maximal concentration was 12 minutes and the maximal blood levels, according to doses, respectively, were 0.153, 0.308, 0.350 and 0.376 µ,g/ml. Besides. mean existence times were, respectively, 4.53±0.20, 3.50±0.03, 3.46±0.05 and 3.43±0.12 hours and AUC values according to doses were, respectively, 33.50±2.62, 45.40±1.84, 48.91±2.77 and 58.47±2.54 µg.hour/ml were observed. The distribution half-lifes of blood thiocyanate levels were, respectively, 0.07±0.008, 0.09±0.005, 0.09±0.005 and 0.18±0.05 hours; the elimination hall-lifes were, respectively, 62.80±19.36, 25.79±2.65, 14.48±0.41 and 14.53±0.80 hours; the duration of maximal concentration 120 minutes and the maximal blood levels according to doses were, respectively, 0.265, 0246, 0.408 and 0.444 µg/ml. Besides, mean existence times were, respectively, 90.27±27.95, 37.37±3.83, 21.04±0.59 and 21.27±1.17 hours and AUC values according to doses were, respectively, 79.13±54.19, 28.06±15.38, 8.92±0.45 and 89.22±49.91 µg.hour/ml.http://eurasianjvetsci.org/pdf.php3?id=481cyanidethiocyanatebloodtoxicokineticmice |
| spellingShingle | Sadettin Tanyıldızı İbrahim Pirinçci Sezai Kaya Bünyamin Traş Ender Yersan The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice Eurasian Journal of Veterinary Sciences cyanide thiocyanate blood toxicokinetic mice |
| title | The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice |
| title_full | The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice |
| title_fullStr | The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice |
| title_full_unstemmed | The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice |
| title_short | The investigation of toxicokinetics parameters of cyanide and thiocyanate in mice |
| title_sort | investigation of toxicokinetics parameters of cyanide and thiocyanate in mice |
| topic | cyanide thiocyanate blood toxicokinetic mice |
| url | http://eurasianjvetsci.org/pdf.php3?id=481 |
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